New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape

• Chad R. Schultz,
• Ryan D. Sheldon,
• Huirong Xie,
• Elena Y. Demireva,
• Katie L. Uhl,
• Dalen W. Agnew,
• Dirk Geerts,
• André S. Bachmann

Affiliations

Chad R. Schultz

Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA

Ryan D. Sheldon

Core Technologies and Services, Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI 49503, USA

Huirong Xie

Transgenic and Genome Editing Facility, Institute for Quantitative Health Science and Engineering, Research Technology Support Facility, Michigan State University, East Lansing, MI 48824, USA

Elena Y. Demireva

Transgenic and Genome Editing Facility, Institute for Quantitative Health Science and Engineering, Research Technology Support Facility, Michigan State University, East Lansing, MI 48824, USA

Katie L. Uhl

Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA

Dalen W. Agnew

Department of Pathobiology & Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA

Dirk Geerts

Department of Hematology, Amsterdam University Medical Center, Location VUMC, 1081 HV Amsterdam, The Netherlands

André S. Bachmann

Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA