An inner activation gate controls TMEM16F phospholipid scrambling

Trieu Le; Zhiguang Jia; Son C. Le; Yang Zhang; Jianhan Chen; Huanghe Yang

doi:10.1038/s41467-019-09778-7

Nature Communications (Apr 2019)

An inner activation gate controls TMEM16F phospholipid scrambling

Trieu Le,
Zhiguang Jia,
Son C. Le,
Yang Zhang,
Jianhan Chen,
Huanghe Yang

Affiliations

Trieu Le: Department of Biochemistry, Duke University Medical Center
Zhiguang Jia: Department of Chemistry, University of Massachusetts
Son C. Le: Department of Biochemistry, Duke University Medical Center
Yang Zhang: Department of Biochemistry, Duke University Medical Center
Jianhan Chen: Department of Chemistry, University of Massachusetts
Huanghe Yang: Department of Biochemistry, Duke University Medical Center

DOI: https://doi.org/10.1038/s41467-019-09778-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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TMEM16F is an enigmatic Ca2 + -activated phospholipid scramblase (CaPLSase) that passively transports phospholipids. Here authors identify an inner activation gate and its disruption profoundly alters TMEM16F phospholipid permeation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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