Communications Biology (Sep 2021)

3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas

  • Max Hahn,
  • Christoffer Nord,
  • Maria Eriksson,
  • Federico Morini,
  • Tomas Alanentalo,
  • Olle Korsgren,
  • Ulf Ahlgren

DOI
https://doi.org/10.1038/s42003-021-02589-x
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 10

Abstract

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Hahn et al. present a method to visualize the endocrine human pancreas in 3D and calculate volumetric data. Using immunolabeling to visualize targets of interest and in reconstructing large tissue parts from imaged cm3-sized tissue blocks, they use their method to reveal previously unknown morphological differences in the endocrine pancreas affected with type 2 diabetes.