Frontiers in Pharmacology (Dec 2021)

Case Report: Response to Almonertinib in a Patient With Metastatic NSCLC Resistant to Osimertinib due to Acquired EGFR L718Q Mutation

  • Gang Shen,
  • Lei Shi,
  • Xin Tian,
  • Depei Huang,
  • Hao Chen,
  • Chan Gao,
  • Xudong Shen,
  • Hushan Zhang

DOI
https://doi.org/10.3389/fphar.2021.731895
Journal volume & issue
Vol. 12

Abstract

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Osimertinib shows strong clinical activity in first- and second-line treatment of nonsmall-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, especially EGFR T790M. However, when patients develop resistance, there is currently no definite postosimertinib treatment option. Herein, we report a patient with metastatic NSCLC who benefited from almonertinib after developing resistance to osimertinib.

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