Antibody-mediated autoimmune encephalitis evaluated by 18F-DPA714 PET/MRI

Ruinan Shen; Dingding Shen; Qinming Zhou; Min Zhang; Sheng Chen

Brain, Behavior, & Immunity - Health (Dec 2022)

Antibody-mediated autoimmune encephalitis evaluated by 18F-DPA714 PET/MRI

Ruinan Shen,
Dingding Shen,
Qinming Zhou,
Min Zhang,
Sheng Chen

Affiliations

Ruinan Shen: Department of Neurology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Dingding Shen: Department of Neurology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Qinming Zhou: Department of Neurology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
Min Zhang: Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding author. Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Sheng Chen: Department of Neurology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China; Corresponding author. Department of Neurology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Journal volume & issue: Vol. 26
p. 100535

Abstract

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SARS-CoV-2 vaccine has considered being the most effective method to prevent SARS-CoV-2 infection. The safety and effectiveness of the SARS-CoV-2 vaccine has been confirmed. However, in very rare cases, autoimmune neurological diseases may occur. In this article, we report three rare cases of autoimmune encephalitis with definite auto-antibody after SARS-CoV-2 vaccination. They all have good prognosis after treatment. In addition, we first use 18F-DPA-714 PET/MRI to evaluate microglia activation in our patients. We found that 18F-DPA-714 PET/MRI may be a powerful tool for quantitative analysis of neuroinflammation in patients of autoimmune encephalitis. Finally, although rare complications may happen after vaccination, we still consider the benefits of vaccination far outweigh the risks. People without contraindications should be vaccinated without delay to prevent infection in current outbreak situation.

Published in Brain, Behavior, & Immunity - Health

ISSN: 2666-3546 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-behavior-and-immunity-health

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