Multi‐vital on‐skin optoelectronic biosensor for assessing regional tissue hemodynamics
Ming Xin,
Tong Yu,
Yongchang Jiang,
Ruowen Tao,
Jiean Li,
Feng Ran,
Tangsong Zhu,
Jinrong Huang,
Jing Zhang,
Jia‐Han Zhang,
Nan Hu,
Wei Wang,
Qiuhong Zhang,
Zhao Liu,
Xinran Wang,
Yi Shi,
Lijia Pan
Affiliations
Ming Xin
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Tong Yu
Department of Vascular Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China
Yongchang Jiang
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Ruowen Tao
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Jiean Li
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Feng Ran
Department of Vascular Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China
Tangsong Zhu
Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering Nanjing University Nanjing China
Jinrong Huang
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Jing Zhang
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Jia‐Han Zhang
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Nan Hu
Department of Vascular Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China
Wei Wang
Department of Vascular Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China
Qiuhong Zhang
Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering Nanjing University Nanjing China
Zhao Liu
Department of Vascular Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China
Xinran Wang
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Yi Shi
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Lijia Pan
Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering Nanjing University Nanjing China
Abstract Evaluation of the oxygen‐mediated effects of clinical and daily activities demands an on‐skin device that can track multi‐vital regional tissue hemodynamics simultaneously. For example, peripheral arterial disease (PAD) is the third most prevalent cardiovascular disease, but the means of diagnosing and monitoring this disease are limited because the affected area is usually in the non‐pulsatile area away from the heart. Herein, we report on an ultrathin and ultralight multi‐vital near‐infrared optoelectronic biosensor for the diagnosis and rehabilitation monitoring of regional tissue hemodynamics, which is suitable for mounting on the skin for long‐term measurement. The device can simultaneously detect tissue oxygen saturation, heart rate, arterial blood oxygen, and tissue perfusion and shows potential for various hypoxia monitoring applications. Moreover, the tissue hemodynamics detected by this device showed a highly accordance with the ankle‐brachial index and CT angiography obtained by traditional clinical methods. Therefore, our design was able to accurately diagnose and effectively evaluate PAD patients before and after surgery. The on‐skin optoelectronic biosensor shows potential in biological oxygen‐mediated behavior evaluation, injury‐state monitoring, PAD clinical diagnosis optimization, and after surgery care.
