Nature Communications (May 2022)
Robust temporal map of human in vitro myelopoiesis using single-cell genomics
- Clara Alsinet,
- Maria Nascimento Primo,
- Valentina Lorenzi,
- Erica Bello,
- Iva Kelava,
- Carla P. Jones,
- Roser Vilarrasa-Blasi,
- Carmen Sancho-Serra,
- Andrew J. Knights,
- Jong-Eun Park,
- Beata S. Wyspianska,
- Gosia Trynka,
- David F. Tough,
- Andrew Bassett,
- Daniel J. Gaffney,
- Damiana Alvarez-Errico,
- Roser Vento-Tormo
Affiliations
- Clara Alsinet
- Wellcome Sanger Institute, Wellcome Genome Campus
- Maria Nascimento Primo
- Wellcome Sanger Institute, Wellcome Genome Campus
- Valentina Lorenzi
- Wellcome Sanger Institute, Wellcome Genome Campus
- Erica Bello
- Wellcome Sanger Institute, Wellcome Genome Campus
- Iva Kelava
- Wellcome Sanger Institute, Wellcome Genome Campus
- Carla P. Jones
- Wellcome Sanger Institute, Wellcome Genome Campus
- Roser Vilarrasa-Blasi
- Wellcome Sanger Institute, Wellcome Genome Campus
- Carmen Sancho-Serra
- Wellcome Sanger Institute, Wellcome Genome Campus
- Andrew J. Knights
- Wellcome Sanger Institute, Wellcome Genome Campus
- Jong-Eun Park
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
- Beata S. Wyspianska
- Open Targets, Wellcome Genome Campus
- Gosia Trynka
- Wellcome Sanger Institute, Wellcome Genome Campus
- David F. Tough
- Immunology Research Unit, Medicines Research Centre, GlaxoSmithKline
- Andrew Bassett
- Wellcome Sanger Institute, Wellcome Genome Campus
- Daniel J. Gaffney
- Wellcome Sanger Institute, Wellcome Genome Campus
- Damiana Alvarez-Errico
- Josep Carreras Leukaemia Research Institute (IJC)
- Roser Vento-Tormo
- Wellcome Sanger Institute, Wellcome Genome Campus
- DOI
- https://doi.org/10.1038/s41467-022-30557-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The myeloid lineage is central to homeostasis and immunity. The authors provide an atlas of human iPSC-to-myeloid cell differentiation and demonstrate that the in vitro system recapitulates yolk sac differentiation, opening new avenues to human myelopoiesis.
