Nature Communications (Sep 2021)
Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease
- Satoshi Watanabe,
- Tohru Kurotani,
- Tomofumi Oga,
- Jun Noguchi,
- Risa Isoda,
- Akiko Nakagami,
- Kazuhisa Sakai,
- Keiko Nakagaki,
- Kayo Sumida,
- Kohei Hoshino,
- Koichi Saito,
- Izuru Miyawaki,
- Masayuki Sekiguchi,
- Keiji Wada,
- Takafumi Minamimoto,
- Noritaka Ichinohe
Affiliations
- Satoshi Watanabe
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Tohru Kurotani
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Tomofumi Oga
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Jun Noguchi
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Risa Isoda
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Akiko Nakagami
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Kazuhisa Sakai
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Keiko Nakagaki
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Kayo Sumida
- Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Konohana-ku
- Kohei Hoshino
- Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd., Konohana-ku
- Koichi Saito
- Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Konohana-ku
- Izuru Miyawaki
- Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd., Konohana-ku
- Masayuki Sekiguchi
- Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Keiji Wada
- Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- Takafumi Minamimoto
- Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba
- Noritaka Ichinohe
- Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
- DOI
- https://doi.org/10.1038/s41467-021-25487-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Non-human primate models of autism spectrum disorder (ASD) are few and not well characterised. Here, the authors describe synaptic function and gene expression changes in a marmoset model of ASD from birth to juvenile, highlighting its similarity to features observed in human ASD.
