Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral <em>Echinomuricea</em> sp.

Abstract

A new clerodane-type diterpenoid, echinoclerodane A (<strong>1</strong>), was isolated from a Formosan gorgonian coral <em>Echinomuricea</em> sp. The structure of <strong>1</strong> was elucidated by spectroscopic methods. Echinoclerodane A (<strong>1</strong>) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (<strong>1</strong>) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

Keywords

• &lt;em&gt;Echinomuricea&lt;/em&gt;
• clerodane diterpene
• echinoclerodane
• cytotoxicity
• superoxide anion
• elastase