Molecules (Nov 2014)

Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

  • Nguyen Ngoc Chuong,
  • Nguyen Thi Thu Huong,
  • Tran Manh Hung,
  • Tran Cong Luan

DOI
https://doi.org/10.3390/molecules191119172
Journal volume & issue
Vol. 19, no. 11
pp. 19172 – 19179

Abstract

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A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.

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