Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis
Nguyen Ngoc Chuong,
Nguyen Thi Thu Huong,
Tran Manh Hung,
Tran Cong Luan
Affiliations
Nguyen Ngoc Chuong
Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam
Nguyen Thi Thu Huong
Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam
Tran Manh Hung
Faculty of Chemistry, University of Science, Vietnam National University-HoChiMinh City, 227 Nguyen Van Cu, District 5, Ho Chi Minh City 227-01, Vietnam
Tran Cong Luan
Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam
A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors.
