The 1,3-dipolar cycloaddition of 1-methylphthalazinium ylides to non-symmetrically activated alkynes on a solid support under microwave irradiation

Abstract

In this paper, a comparative study of the reaction of 1-methylpihthalazinium ylides with nonsymmetrically activated alkynes in a solid media by classical heating and under microwaves is presented. The reactants were impregnated on a mineral support (Al2O3 – KF) or irradiation were brought into catalytic conditions through interphase solide – liquid transfer in the absence of a solvent and were then subjected to microwave. The reaction of 1-methylphthalazinium ylides with nonsymmetrically activated alkynes on a mineral support and in phase transfer catalysis under microwave irradiation is a regioselective reaction and results in larger yields in a shorter time than under classical conditions.

Keywords

• 3+2 dipolar cycloaddition
• phase transfer catalysis
• microwaves