Indian Journal of Pathology and Microbiology (Jan 2022)

Phosphaturic mesenchymal tumor: An underdiagnosed rare entity

  • Sanjiban Patra,
  • Priti Trivedi,
  • Chirag Jhaveri

DOI
https://doi.org/10.4103/ijpm.ijpm_1341_20
Journal volume & issue
Vol. 65, no. 1
pp. 181 – 183

Abstract

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Tumor-induced osteomalacia is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. Phosphaturic mesenchymal tumors represent a rare etiology of tumor-induced osteomalacia. They are exceptionally rare, probably accounting for < 0.01% of all soft tissue tumors. Most PMTs present as small inapparent lesions that require very careful clinical examination and radionucleotide scan for localization. Here we describe a case in a 65 years old woman with recurrent multiple bone fractures and subsequent detection of a tumor involving right femur and adjacent soft tissue, low phosphate level and elevated serum Fibroblast growth factor-23 (FGF-23).

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