Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance

Marie Villares; Nelly Lourenço; Jeremy Berthelet; Suzanne Lamotte; Leslie Regad; Souhila Medjkane; Eric Prina; Fernando Rodrigues-Lima; Gerald F. Späth; Jonathan B. Weitzman

doi:10.1038/s42003-022-03981-x

Communications Biology (Nov 2022)

Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance

Marie Villares,
Nelly Lourenço,
Jeremy Berthelet,
Suzanne Lamotte,
Leslie Regad,
Souhila Medjkane,
Eric Prina,
Fernando Rodrigues-Lima,
Gerald F. Späth,
Jonathan B. Weitzman

Affiliations

Marie Villares: Université Paris Cité, Epigenetics and Cell Fate, CNRS
Nelly Lourenço: Université Paris Cité, Epigenetics and Cell Fate, CNRS
Jeremy Berthelet: Université Paris Cité, Epigenetics and Cell Fate, CNRS
Suzanne Lamotte: Institut Pasteur, Université Paris Cité, INSERM U1201, Molecular Parasitology and Signaling Unit
Leslie Regad: Université Paris Cité, BFA, UMR 8251, CNRS, ERL U1133, Inserm
Souhila Medjkane: Université Paris Cité, Epigenetics and Cell Fate, CNRS
Eric Prina: Institut Pasteur, Université Paris Cité, INSERM U1201, Molecular Parasitology and Signaling Unit
Fernando Rodrigues-Lima: Université Paris Cité, BFA, UMR 8251, CNRS, ERL U1133, Inserm
Gerald F. Späth: Institut Pasteur, Université Paris Cité, INSERM U1201, Molecular Parasitology and Signaling Unit
Jonathan B. Weitzman: Université Paris Cité, Epigenetics and Cell Fate, CNRS

DOI: https://doi.org/10.1038/s42003-022-03981-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

Read online

A microscopy-based screen of Medicines for Malaria Venture Pathogen Box identifies Trifloxystrobin as an effective alternative to Buparvaquone treatment for Theileria parasites infection, by inhibiting parasite survival and differentiation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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