Non-Coding RNAs as Prognostic Markers for Endometrial Cancer

Roberto Piergentili; Simona Zaami; Anna Franca Cavaliere; Fabrizio Signore; Giovanni Scambia; Alberto Mattei; Enrico Marinelli; Caterina Gulia; Federica Perelli

doi:10.3390/ijms22063151

International Journal of Molecular Sciences (Mar 2021)

Non-Coding RNAs as Prognostic Markers for Endometrial Cancer

Roberto Piergentili,
Simona Zaami,
Anna Franca Cavaliere,
Fabrizio Signore,
Giovanni Scambia,
Alberto Mattei,
Enrico Marinelli,
Caterina Gulia,
Federica Perelli

Affiliations

Roberto Piergentili: Institute of Molecular Biology and Pathology, Italian National Research Council (CNR-IBPM), 00185 Rome, Italy
Simona Zaami: Department of Anatomical, Histological, Forensic and Orthopedic Sciences, “Sapienza” University of Rome, Viale Regina Elena 336, 00161 Rome, Italy
Anna Franca Cavaliere: Gynecology and Obstetric Department, Azienda USL Toscana Centro, Santo Stefano Hospital, 59100 Prato, Italy
Fabrizio Signore: Obstetrics and Gynecology Department, USL Roma2, Sant’Eugenio Hospital, 00144 Rome, Italy
Giovanni Scambia: Fondazione Policlinico Universitario A. Gemelli IRCCS, Gynecologic Oncology Unit, 00168 Rome, Italy
Alberto Mattei: Gynecology and Obstetric Department, Azienda USL Toscana Centro, Santa Maria Annunziata Hospital, 50012 Florence, Italy
Enrico Marinelli: Unit of Forensic Toxicology (UoFT), Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University, 00161 Rome, Italy
Caterina Gulia: Department of Urology, Misericordia Hospital, 58100 Grosseto, Italy
Federica Perelli: Gynecology and Obstetric Department, Azienda USL Toscana Centro, Santa Maria Annunziata Hospital, 50012 Florence, Italy

DOI: https://doi.org/10.3390/ijms22063151
Journal volume & issue: Vol. 22, no. 6
p. 3151

Abstract

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Endometrial cancer (EC) has been classified over the years, for prognostic and therapeutic purposes. In recent years, classification systems have been emerging not only based on EC clinical and pathological characteristics but also on its genetic and epigenetic features. Noncoding RNAs (ncRNAs) are emerging as promising markers in several cancer types, including EC, for which their prognostic value is currently under investigation and will likely integrate the present prognostic tools based on protein coding genes. This review aims to underline the importance of the genetic and epigenetic events in the EC tumorigenesis, by expounding upon the prognostic role of ncRNAs.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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