PSMA-PET/CT-Positive Paget Disease in a Patient with Newly Diagnosed Prostate Cancer: Imaging and Bone Biopsy Findings

Michael Froehner; Marieta Toma; Klaus Zöphel; Vladimir Novotny; Michael Laniado; Manfred P. Wirth

doi:10.1155/2017/1654231

Case Reports in Urology (Jan 2017)

PSMA-PET/CT-Positive Paget Disease in a Patient with Newly Diagnosed Prostate Cancer: Imaging and Bone Biopsy Findings

Michael Froehner,
Marieta Toma,
Klaus Zöphel,
Vladimir Novotny,
Michael Laniado,
Manfred P. Wirth

Affiliations

Michael Froehner: Departments of Urology, University Hospital “Carl Gustav Carus”, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Marieta Toma: Departments of Pathology, University Hospital “Carl Gustav Carus”, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Klaus Zöphel: Departments of Nuclear Medicine, University Hospital “Carl Gustav Carus”, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Vladimir Novotny: Departments of Urology, University Hospital “Carl Gustav Carus”, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Michael Laniado: Departments of Radiologic Diagnostics, University Hospital “Carl Gustav Carus”, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Manfred P. Wirth: Departments of Urology, University Hospital “Carl Gustav Carus”, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany

DOI: https://doi.org/10.1155/2017/1654231
Journal volume & issue: Vol. 2017

Abstract

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A 67-year-old man diagnosed with Gleason score 4+5=9 clinically localized prostate cancer with 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) positive Paget bone disease is described. Immunohistochemical staining revealed weak PSMA positivity of the bone lesion supporting the hypothesis that neovasculature might explain positive PSMA-PET/CT findings in Paget disease.

Published in Case Reports in Urology

ISSN: 2090-696X (Print); 2090-6978 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: https://onlinelibrary.wiley.com/journal/5030

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