Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor

Affiliations

Sucharita Bose: Department of Biological Sciences, Purdue University
C. Nicklaus Steussy: Department of Biological Sciences, Purdue University
Daneli López-Pérez: Department of Chemistry, Purdue University
Tim Schmidt: Department of Biological Sciences, Purdue University
Samadhi C. Kulathunga: Department of Biological Sciences, Purdue University
Mohamed N. Seleem: Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University
Mark Lipton: Department of Chemistry, Purdue University
Andrew D. Mesecar: Department of Biological Sciences, Purdue University
Victor W. Rodwell: Department of Biochemistry, Purdue University
Cynthia V. Stauffacher: Department of Biological Sciences, Purdue University

Abstract

High-throughput in vitro screening and crystal structures identify a non-statin inhibitor of HMG-CoA reductase for novel antibacterial drug design.