Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients

Abstract

Myocardial infarction (MI) is a multifactorial coronary artery disease influenced by environmental and genetic factors. Being one of the leading causes of morbidity and mortality in developed countries, it is becoming a national health concern in developing countries such as Morocco. In the present work, we aim to study the association between 4 Alu polymorphisms (ACE, FXIII-B, TPA-25 and APOA1) genes and the risk of MI in the Moroccan population. 210 patients with a history of myocardial infarction and 203 healthy individuals were included in this study. The Alu polymorphisms were determined by the PCR technique followed by direct electrophoresis. Only the I / I_APOA1 genotype showed a significant association with the risk of MI (p˂0.001; OR = 2.171), while genotypes carrying the D allele (D / D or I / D) showed a protective effect (p <0.001; OR = 0.46). Patients presenting an association between I / I and a high level of triglycerides (p = 0.020, OR = 2.14)), as well as a significant association with a high level of LDLs (p = 0.035, OR = 2, 00). Subjects carrying the I / I_APOA1 genotype with dyslipidemia or hyperglycemia are more likely to develop MI, as are those carrying I / D_APOA1 with hyperglycemia or high cholesterol.

Keywords

• myocardial infarction
• polymorphism
• alu apoa1
• hyperglycemia
• dyslipidemia