Communications Biology (Feb 2023)
The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions
- Mara Stellato,
- Matthias Dewenter,
- Michal Rudnik,
- Amela Hukara,
- Çagla Özsoy,
- Florian Renoux,
- Elena Pachera,
- Felix Gantenbein,
- Petra Seebeck,
- Siim Uhtjaerv,
- Elena Osto,
- Daniel Razansky,
- Karin Klingel,
- Joerg Henes,
- Oliver Distler,
- Przemysław Błyszczuk,
- Gabriela Kania
Affiliations
- Mara Stellato
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Matthias Dewenter
- Institute of Experimental Cardiology, University Hospital
- Michal Rudnik
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Amela Hukara
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Çagla Özsoy
- Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich
- Florian Renoux
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Elena Pachera
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Felix Gantenbein
- Zurich integrative Rodent Physiology, University of Zurich
- Petra Seebeck
- Zurich integrative Rodent Physiology, University of Zurich
- Siim Uhtjaerv
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Elena Osto
- Institute of Clinical Chemistry, University Hospital Zurich
- Daniel Razansky
- Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich
- Karin Klingel
- Cardiopathology, Institute for Pathology and Neuropathology, University Hospital Tubingen
- Joerg Henes
- Internal Medicine II, Division of Rheumatology, University Hospital Tubingen
- Oliver Distler
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Przemysław Błyszczuk
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- Gabriela Kania
- Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich
- DOI
- https://doi.org/10.1038/s42003-023-04534-6
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 15
Abstract
The role of the transcription factor Fosl-2 in promoting myocardial fibrosis, arrhythmias and aberrant response to stress under immunofibrotic conditions is described using an in vivo mouse model and human cardiac fibroblasts.
