Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

Chi Lam Au Yeung; Ngai-Na Co; Tetsushi Tsuruga; Tsz-Lun Yeung; Suet-Ying Kwan; Cecilia S. Leung; Yong Li; Edward S. Lu; Kenny Kwan; Kwong-Kwok Wong; Rosemarie Schmandt; Karen H. Lu; Samuel C. Mok

doi:10.1038/ncomms11150

Nature Communications (Mar 2016)

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

Chi Lam Au Yeung,
Ngai-Na Co,
Tetsushi Tsuruga,
Tsz-Lun Yeung,
Suet-Ying Kwan,
Cecilia S. Leung,
Yong Li,
Edward S. Lu,
Kenny Kwan,
Kwong-Kwok Wong,
Rosemarie Schmandt,
Karen H. Lu,
Samuel C. Mok

Affiliations

Chi Lam Au Yeung: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Ngai-Na Co: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Tetsushi Tsuruga: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Tsz-Lun Yeung: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Suet-Ying Kwan: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Cecilia S. Leung: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Yong Li: Department of Biochemistry and Molecular Biology, University of Louisville
Edward S. Lu: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Kenny Kwan: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Kwong-Kwok Wong: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Rosemarie Schmandt: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Karen H. Lu: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Samuel C. Mok: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms11150
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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The tumor microenviroment can influence cancer progression and response to therapy. In this study, the authors show that miR21 is transferred through exosomes from cancer-associated fibroblasts and adipocytes to ovarian cancer cells where it modulates drug resistance by its direct target APAF1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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