Frontiers in Aging Neuroscience (2020-10-01)

Glycyrrhizic Acid Improves Cognitive Levels of Aging Mice by Regulating T/B Cell Proliferation

  • Ruichan Jiang,
  • Jiaming Gao,
  • Junyan Shen,
  • Xiaoqi Zhu,
  • Hao Wang,
  • Shengyu Feng,
  • Ce Huang,
  • Haitao Shen,
  • Hailiang Liu,
  • Hailiang Liu

Journal volume & issue
Vol. 12


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Glycyrrhizic acid (GA) is the substance with the highest content of triterpenoid saponins that can be extracted from licorice, and has anti-inflammatory, neuroprotective, and anticancer functions, among others. The aim of this study was to investigate the protective effect of GA on cognitive decline in middle-aged mice and explore its mechanisms. We injected GA by the tail vein of C57BL/6 mice and measured their cognitive levels using the Morris water maze. The Morris water maze results demonstrated that GA improved learning and memory abilities in middle-aged mice. Furthermore, the RNA-sequencing and flow cytometric analyses revealed that GA could increase T and B cells. We then confirmed the relationship between cognition and the immune system in the immune-deficient B-NDG mouse model. Our results suggest that GA improves cognition in aging mice by regulating T/B cell proliferation.