Nature Communications (Aug 2022)

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity

  • Lijun Dong,
  • Jingwen Xie,
  • Youyi Wang,
  • Honglian Jiang,
  • Kai Chen,
  • Dantong Li,
  • Jing Wang,
  • Yunzhi Liu,
  • Jia He,
  • Jia Zhou,
  • Liyun Zhang,
  • Xiao Lu,
  • Xiaoming Zou,
  • Xiang-Yang Wang,
  • Qingqing Wang,
  • Zhengliang Chen,
  • Daming Zuo

DOI
https://doi.org/10.1038/s41467-022-32505-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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New potential therapies for inflammatory bowel disease are needed as not all patients respond to or maintain a response to conventional therapies. Here the authors report that mannose supplementation ameliorates experimental colitis in male mice, potentially via effects on intestinal epithelium lysosomal integrity.