Nature Communications (Aug 2022)
Mannose ameliorates experimental colitis by protecting intestinal barrier integrity
- Lijun Dong,
- Jingwen Xie,
- Youyi Wang,
- Honglian Jiang,
- Kai Chen,
- Dantong Li,
- Jing Wang,
- Yunzhi Liu,
- Jia He,
- Jia Zhou,
- Liyun Zhang,
- Xiao Lu,
- Xiaoming Zou,
- Xiang-Yang Wang,
- Qingqing Wang,
- Zhengliang Chen,
- Daming Zuo
Affiliations
- Lijun Dong
- The Fifth Affiliated Hospital, Southern Medical University
- Jingwen Xie
- Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University
- Youyi Wang
- Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University
- Honglian Jiang
- Guangdong Provincial Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University
- Kai Chen
- Guangdong Provincial Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University
- Dantong Li
- Guangdong Provincial Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University
- Jing Wang
- Department of Gastroenterology, Nanfang Hospital, Southern Medical University
- Yunzhi Liu
- Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University
- Jia He
- Institute of Immunology, Zhejiang University School of Medicine
- Jia Zhou
- Guangdong Provincial Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University
- Liyun Zhang
- Guangdong Provincial Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University
- Xiao Lu
- Guangdong Provincial Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University
- Xiaoming Zou
- The Fifth Affiliated Hospital, Southern Medical University
- Xiang-Yang Wang
- Department of Human and Molecular Genetics, Virginia Commonwealth University
- Qingqing Wang
- Institute of Immunology, Zhejiang University School of Medicine
- Zhengliang Chen
- Guangdong Provincial Key Laboratory of Proteomics, Department of Immunology, School of Basic Medical Sciences, Southern Medical University
- Daming Zuo
- The Fifth Affiliated Hospital, Southern Medical University
- DOI
- https://doi.org/10.1038/s41467-022-32505-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
New potential therapies for inflammatory bowel disease are needed as not all patients respond to or maintain a response to conventional therapies. Here the authors report that mannose supplementation ameliorates experimental colitis in male mice, potentially via effects on intestinal epithelium lysosomal integrity.
