IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

Stella Amanda; Tze King Tan; Jolynn Zu Lin Ong; Madelaine Skolastika Theardy; Regina Wan Ju Wong; Xiao Zi Huang; Muhammad Zulfaqar Ali; Yan Li; Zhiyuan Gong; Hiroshi Inagaki; Ee Yong Foo; Brendan Pang; Soo Yong Tan; Shinsuke Iida; Takaomi Sanda

doi:10.1038/s41467-022-30053-9

Nature Communications (May 2022)

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

Stella Amanda,
Tze King Tan,
Jolynn Zu Lin Ong,
Madelaine Skolastika Theardy,
Regina Wan Ju Wong,
Xiao Zi Huang,
Muhammad Zulfaqar Ali,
Yan Li,
Zhiyuan Gong,
Hiroshi Inagaki,
Ee Yong Foo,
Brendan Pang,
Soo Yong Tan,
Shinsuke Iida,
Takaomi Sanda

Affiliations

Stella Amanda: Cancer Science Institute of Singapore, National University of Singapore
Tze King Tan: Cancer Science Institute of Singapore, National University of Singapore
Jolynn Zu Lin Ong: Cancer Science Institute of Singapore, National University of Singapore
Madelaine Skolastika Theardy: Cancer Science Institute of Singapore, National University of Singapore
Regina Wan Ju Wong: Cancer Science Institute of Singapore, National University of Singapore
Xiao Zi Huang: Cancer Science Institute of Singapore, National University of Singapore
Muhammad Zulfaqar Ali: Cancer Science Institute of Singapore, National University of Singapore
Yan Li: Department of Biological Sciences, National University of Singapore
Zhiyuan Gong: Department of Biological Sciences, National University of Singapore
Hiroshi Inagaki: Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences
Ee Yong Foo: Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore
Brendan Pang: Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore
Soo Yong Tan: Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore
Shinsuke Iida: Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences
Takaomi Sanda: Cancer Science Institute of Singapore, National University of Singapore

DOI: https://doi.org/10.1038/s41467-022-30053-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

IRF4 is a regulator of immune function, and is overexpressed in lymphoid neoplasms. Here, the authors utilise single cell RNA-seq to show the abundance of double-negative T cells in IRF4 driven zebrafish tumour models, and identify sensitivity of these tumours to BRD inhibition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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