Lycorine impedes 7,12-dimethylbenz(a)anthracene exposed hamster oral carcinogenesis through P13K/Akt and NF-κB inhibition

Abstract

Oncogenic signaling pathways that are activated abnormally play a key activity in tumor initiation and development. This research aimed to examine the preventive efficiency of lycorine in the buccal pouch hamster tumor model based on its capacity to target phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor-kappa B (NF-κB) signaling cascades.

Keywords

• buccal pouch carcinogenesis
• detoxification agents
• lycorine
• nf-κb signaling
• p13k/akt signaling