Communications Biology (Aug 2021)
Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading
- Dandan Yao,
- Qingyuan He,
- Shangyin Bai,
- Hang Zhao,
- Jun Yang,
- Dehua Cui,
- Yan Yu,
- Xuechao Fei,
- Yufei Mei,
- Ye Cheng,
- Shi Yan,
- Nayan Huang,
- Yalan Di,
- Xianjie Cai,
- Rui Wang,
- Yajuan Gao,
- Fangrao Cheng,
- Shengjie Zhao,
- Xu Yang,
- Xiang Cai,
- Hongbin Han,
- Jihui Lyu,
- Zhiqian Tong
Affiliations
- Dandan Yao
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Qingyuan He
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Shangyin Bai
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Hang Zhao
- Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, School of Mental Health, Wenzhou Medical University
- Jun Yang
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Dehua Cui
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Yan Yu
- Chinese institute of Rehabilitation Science, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation
- Xuechao Fei
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Yufei Mei
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Ye Cheng
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Shi Yan
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Nayan Huang
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Yalan Di
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Xianjie Cai
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Rui Wang
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Yajuan Gao
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Fangrao Cheng
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Shengjie Zhao
- Chinese institute of Rehabilitation Science, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation
- Xu Yang
- Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University
- Xiang Cai
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- Hongbin Han
- Department of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and Technique
- Jihui Lyu
- Center for Cognitive Disorders, Beijing Geriatric Hospital
- Zhiqian Tong
- Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University
- DOI
- https://doi.org/10.1038/s42003-021-02448-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Dandan Yao et al. demonstrated that accumulation of formaldehyde in the cerebellum and skeletal muscle contributed toward motor deficits in a mouse model of hindlimb unloading. Their results collectively suggest that scavenging formaldehyde may be a useful treatment to limit motor dysfunction following limb offloading conditions.
