Nature Communications (Mar 2021)

Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress

  • Nathan Egge,
  • Sonja L. B. Arneaud,
  • Rene Solano Fonseca,
  • Kielen R. Zuurbier,
  • Jacob McClendon,
  • Peter M. Douglas

DOI
https://doi.org/10.1038/s41467-021-21611-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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The nervous system utilizes adaptive strategies to mitigate trauma-induced neurodegeneration. Here, the authors report that a MAPK phosphatase VHP-1 is induced by trauma and regulates transcriptional responses to mechanical stress in a C. elegans model.