Nature Communications (Sep 2021)
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
- Inge de Krijger,
- Bastian Föhr,
- Santiago Hernández Pérez,
- Estelle Vincendeau,
- Judit Serrat,
- Alexander Marc Thouin,
- Vivek Susvirkar,
- Chloé Lescale,
- Inés Paniagua,
- Liesbeth Hoekman,
- Simranjeet Kaur,
- Maarten Altelaar,
- Ludovic Deriano,
- Alex C. Faesen,
- Jacqueline J. L. Jacobs
Affiliations
- Inge de Krijger
- Division of Oncogenomics, The Netherlands Cancer Institute
- Bastian Föhr
- Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry
- Santiago Hernández Pérez
- Division of Oncogenomics, The Netherlands Cancer Institute
- Estelle Vincendeau
- Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur
- Judit Serrat
- Division of Oncogenomics, The Netherlands Cancer Institute
- Alexander Marc Thouin
- Division of Oncogenomics, The Netherlands Cancer Institute
- Vivek Susvirkar
- Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry
- Chloé Lescale
- Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur
- Inés Paniagua
- Division of Oncogenomics, The Netherlands Cancer Institute
- Liesbeth Hoekman
- Proteomics Facility, The Netherlands Cancer Institute
- Simranjeet Kaur
- Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry
- Maarten Altelaar
- Proteomics Facility, The Netherlands Cancer Institute
- Ludovic Deriano
- Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur
- Alex C. Faesen
- Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry
- Jacqueline J. L. Jacobs
- Division of Oncogenomics, The Netherlands Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-021-25724-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
MAD2L2 — a member of the shieldin complex — is known to play important roles in DNA repair. Here the authors demonstrate how MAD2L2 dimerization mediated through SHLD2 participates in shieldin assembly and function.
