Nature Communications (Jan 2021)
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
- Matt Lechner,
- Volker H. Schartinger,
- Christopher D. Steele,
- Wen Long Nei,
- Marc Lucas Ooft,
- Liesa-Marie Schreiber,
- Christodoulos P. Pipinikas,
- Grace Tin-Yun Chung,
- Yuk Yu Chan,
- Feng Wu,
- Ka-Fai To,
- Chi Man Tsang,
- Wayne Pearce,
- Daniele Morelli,
- Martin Philpott,
- Liam Masterson,
- Reshma Nibhani,
- Graham Wells,
- Christopher G. Bell,
- Julia Koller,
- Susanne Delecluse,
- Yim Ling Yip,
- Jacklyn Liu,
- Cillian T. Forde,
- Martin D. Forster,
- Amrita Jay,
- József Dudás,
- Annika Krapp,
- Simon Wan,
- Christian Uprimny,
- Susanne Sprung,
- Johannes Haybaeck,
- Tim R. Fenton,
- Kerry Chester,
- Christina Thirlwell,
- Gary Royle,
- Teresa Marafioti,
- Rajeev Gupta,
- Sagung Rai Indrasari,
- Camelia Herdini,
- Mohd Afiq Mohd Slim,
- I. Indrawati,
- Liam Sutton,
- Renske Fles,
- Bing Tan,
- Joe Yeong,
- Amit Jain,
- Shuting Han,
- Haitao Wang,
- Kelvin S. H. Loke,
- Wan He,
- Ruilian Xu,
- Hongtao Jin,
- Zhiqiang Cheng,
- David Howard,
- Peter H. Hwang,
- Quynh-Thu Le,
- Joshua K. Tay,
- Robert B. West,
- Sai Wah Tsao,
- Tim Meyer,
- Herbert Riechelmann,
- Udo Oppermann,
- Henri-Jacques Delecluse,
- Stefan M. Willems,
- Melvin L. K. Chua,
- Pierre Busson,
- Kwok Wai Lo,
- Guido Wollmann,
- Nischalan Pillay,
- Bart Vanhaesebroeck,
- Valerie J. Lund
Affiliations
- Matt Lechner
- UCL Cancer Institute, University College London
- Volker H. Schartinger
- Department of Otorhinolaryngology, Medical University of Innsbruck
- Christopher D. Steele
- UCL Cancer Institute, University College London
- Wen Long Nei
- Divisions of Radiation Oncology and Medical Sciences, National Cancer Centre
- Marc Lucas Ooft
- King´s College Hospitals, NHS Foundation Trust
- Liesa-Marie Schreiber
- Institute of Virology and Christian Doppler Laboratory for Viral Immunotherapy of Cancer, Medical University of Innsbruck
- Christodoulos P. Pipinikas
- UCL Cancer Institute, University College London
- Grace Tin-Yun Chung
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Yuk Yu Chan
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Feng Wu
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Ka-Fai To
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Chi Man Tsang
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Wayne Pearce
- UCL Cancer Institute, University College London
- Daniele Morelli
- UCL Cancer Institute, University College London
- Martin Philpott
- Botnar Research Centre, University of Oxford
- Liam Masterson
- Department of Otolaryngology, Addenbrooke’s Hospital
- Reshma Nibhani
- Botnar Research Centre, University of Oxford
- Graham Wells
- Botnar Research Centre, University of Oxford
- Christopher G. Bell
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Julia Koller
- Department of Otorhinolaryngology, Medical University of Innsbruck
- Susanne Delecluse
- German Cancer Research Centre (DKFZ) and Inserm, Unit F100/U1074
- Yim Ling Yip
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Jacklyn Liu
- UCL Cancer Institute, University College London
- Cillian T. Forde
- Royal National Throat, Nose and Ear Hospital and Head and Neck Centre, University College London Hospitals NHS Trust
- Martin D. Forster
- UCL Cancer Institute, University College London
- Amrita Jay
- Department of Histopathology, University College London Hospitals NHS Trust
- József Dudás
- Department of Otorhinolaryngology, Medical University of Innsbruck
- Annika Krapp
- Department of Otorhinolaryngology, Medical University of Innsbruck
- Simon Wan
- Institute of Nuclear Medicine, University College Hospital
- Christian Uprimny
- Department of Nuclear Medicine, Medical University of Innsbruck
- Susanne Sprung
- Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck
- Johannes Haybaeck
- Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck
- Tim R. Fenton
- School of Biosciences, University of Kent
- Kerry Chester
- UCL Cancer Institute, University College London
- Christina Thirlwell
- UCL Cancer Institute, University College London
- Gary Royle
- UCL Cancer Institute, University College London
- Teresa Marafioti
- UCL Cancer Institute, University College London
- Rajeev Gupta
- UCL Cancer Institute, University College London
- Sagung Rai Indrasari
- ENT Head and Neck Surgery Department, Universitas Gadjah Mada, Dr. Sardjito Hospital
- Camelia Herdini
- ENT Head and Neck Surgery Department, Universitas Gadjah Mada, Dr. Sardjito Hospital
- Mohd Afiq Mohd Slim
- Department of Ear, Nose and Throat, University Hospital Crosshouse
- I. Indrawati
- Department of Anatomical Pathology, Universitas Gadjah Mada, Dr. Sardjito Hospital
- Liam Sutton
- Barts Health NHS Trust
- Renske Fles
- Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute
- Bing Tan
- ENT Head and Neck Surgery Department, Universitas Gadjah Mada, Dr. Sardjito Hospital
- Joe Yeong
- Department of Anatomical Pathology, Singapore General Hospital
- Amit Jain
- Division of Medical Oncology, National Cancer Centre
- Shuting Han
- Division of Medical Oncology, National Cancer Centre
- Haitao Wang
- Divisions of Radiation Oncology and Medical Sciences, National Cancer Centre
- Kelvin S. H. Loke
- Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital
- Wan He
- Department of Oncology, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University
- Ruilian Xu
- Department of Oncology, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University
- Hongtao Jin
- Department of Pathology, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University
- Zhiqiang Cheng
- Department of Pathology, The Second Clinical Medical College, Shenzhen People’s Hospital, Jinan University
- David Howard
- Royal National Throat, Nose and Ear Hospital and Head and Neck Centre, University College London Hospitals NHS Trust
- Peter H. Hwang
- Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine
- Quynh-Thu Le
- Department of Radiation Oncology, Stanford University School of Medicine
- Joshua K. Tay
- Department of Pathology, Stanford University School of Medicine
- Robert B. West
- Department of Pathology, Stanford University School of Medicine
- Sai Wah Tsao
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Tim Meyer
- UCL Cancer Institute, University College London
- Herbert Riechelmann
- Department of Otorhinolaryngology, Medical University of Innsbruck
- Udo Oppermann
- Botnar Research Centre, University of Oxford
- Henri-Jacques Delecluse
- German Cancer Research Centre (DKFZ) and Inserm, Unit F100/U1074
- Stefan M. Willems
- Department of Pathology, University Medical Center Utrecht
- Melvin L. K. Chua
- Divisions of Radiation Oncology and Medical Sciences, National Cancer Centre
- Pierre Busson
- CNRS-UMR 9018-METSY, Gustave Roussy and Université Paris-Saclay
- Kwok Wai Lo
- Department of Anatomical and Cellular Pathology and State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Guido Wollmann
- Institute of Virology and Christian Doppler Laboratory for Viral Immunotherapy of Cancer, Medical University of Innsbruck
- Nischalan Pillay
- UCL Cancer Institute, University College London
- Bart Vanhaesebroeck
- UCL Cancer Institute, University College London
- Valerie J. Lund
- UCL Cancer Institute, University College London
- DOI
- https://doi.org/10.1038/s41467-020-20308-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Nasopharyngeal carcinoma (NPC) lacks effective diagnostic and therapeutic strategies, in particular at advanced stages. Here, the authors show that expression of the somatostatin receptor 2 is induced by Epstein-Barr virus in NPC and has a key role in the diagnosis, imaging, targeted therapies and prognosis of NPC.
