Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i>
Simone da Cunha Demenciano,
Magalli Costa Barbosa Lima e Silva,
Caroline Almeida Farias Alexandrino,
Wilson Hino Kato Junior,
Patrícia de Oliveira Figueiredo,
Walmir Silva Garcez,
Raquel Pires Campos,
Rita de Cássia Avellaneda Guimarães,
Ulana Chaves Sarmento,
Danielle Bogo
Affiliations
Simone da Cunha Demenciano
Molecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, Brazil
Magalli Costa Barbosa Lima e Silva
Molecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, Brazil
Caroline Almeida Farias Alexandrino
Molecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, Brazil
Wilson Hino Kato Junior
Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul, Cidade Universitária, Campo Grande 79070-900, Brazil
Patrícia de Oliveira Figueiredo
Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul, Cidade Universitária, Campo Grande 79070-900, Brazil
Walmir Silva Garcez
Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil
Raquel Pires Campos
Laboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul, Cidade Universitária, Campo Grande 79070-900, Brazil
Rita de Cássia Avellaneda Guimarães
Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, Brazil
Ulana Chaves Sarmento
Laboratory of Physical Chemistry of Foods, School of Pharmaceutical Sciences, Foods, Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, Brazil
Danielle Bogo
Molecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, Brazil
The aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of Garcinia gardneriana, a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, the following neoplastic cell lines were considered, along with an immortalized nontumor cell line. The antioxidant potential was determined, and the evaluation of antiradical air activity was performed. The levels of vitamin C and carotenoids were determined. The chemical profile was analyzed by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer using electrospray ionization interface. The chloroform fraction of the leaf showed antioxidant activity. The vitamin C content had lower values in fruits and higher in leaves. The content of carotenoids for fruits and leaves was expressive. The ethanolic extract and the hexane and chloroform fractions of fruits were active in all neoplastic lines tested. The leaves showed cytotoxic activity in the hexane fraction in the breast carcinoma line. The analysis of data obtained verified the presence of dimers, monomers, and tetramers of hexoses, polycarboxylic acids, xanthones, flavonoids, biflavonoids, and benzophenones.
