Nature Communications (Apr 2018)
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
- Hui Li,
- Qi Yao,
- Alberto Garcia Mariscal,
- Xudong Wu,
- Justus Hülse,
- Esben Pedersen,
- Kristian Helin,
- Ari Waisman,
- Caroline Vinkel,
- Simon Francis Thomsen,
- Alexandra Avgustinova,
- Salvador Aznar Benitah,
- Paola Lovato,
- Hanne Norsgaard,
- Mette Sidsel Mortensen,
- Lone Veng,
- Björn Rozell,
- Cord Brakebusch
Affiliations
- Hui Li
- Department of Biomedical Sciences, University of Copenhagen
- Qi Yao
- Department of Biomedical Sciences, University of Copenhagen
- Alberto Garcia Mariscal
- Department of Biomedical Sciences, University of Copenhagen
- Xudong Wu
- Biotech Research and Innovation Centre (BRIC)
- Justus Hülse
- Department of Biomedical Sciences, University of Copenhagen
- Esben Pedersen
- Department of Biomedical Sciences, University of Copenhagen
- Kristian Helin
- Biotech Research and Innovation Centre (BRIC)
- Ari Waisman
- Institute for Molecular Medicine, Johannes Gutenberg-University Mainz
- Caroline Vinkel
- Department of Dermatology, Copenhagen University Hospital Bispebjerg
- Simon Francis Thomsen
- Department of Dermatology, Copenhagen University Hospital Bispebjerg
- Alexandra Avgustinova
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Salvador Aznar Benitah
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Paola Lovato
- LEO Pharma A/S
- Hanne Norsgaard
- LEO Pharma A/S
- Mette Sidsel Mortensen
- LEO Pharma A/S
- Lone Veng
- LEO Pharma A/S
- Björn Rozell
- Department of Experimental Medicine, University of Copenhagen
- Cord Brakebusch
- Department of Biomedical Sciences, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-018-03704-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Although IL-23 is expressed by psoriatic keratinocytes as well as immune cells, only the immune cell derived IL-23 is thought to be important for the development of psoriasis. Here the authors provide evidence that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation.
