Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila

Kyra Kerkhofs; Jyoti Garg; Étienne Fafard-Couture; Sherif Abou Elela; Michelle S. Scott; Ronald E. Pearlman; Mark A. Bayfield

doi:10.1038/s41467-022-34796-3

Nature Communications (Nov 2022)

Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila

Kyra Kerkhofs,
Jyoti Garg,
Étienne Fafard-Couture,
Sherif Abou Elela,
Michelle S. Scott,
Ronald E. Pearlman,
Mark A. Bayfield

Affiliations

Kyra Kerkhofs: Department of Biology, Faculty of Science, York University
Jyoti Garg: Department of Biology, Faculty of Science, York University
Étienne Fafard-Couture: Département de Biochimie et de Génomique Fonctionnelle, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke
Sherif Abou Elela: Département de Microbiologie et d’Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke
Michelle S. Scott: Département de Biochimie et de Génomique Fonctionnelle, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke
Ronald E. Pearlman: Department of Biology, Faculty of Science, York University
Mark A. Bayfield: Department of Biology, Faculty of Science, York University

DOI: https://doi.org/10.1038/s41467-022-34796-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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La proteins are conserved factors critical for the maturation of RNA polymerase III transcripts. In the ciliate T. thermophila and related alveolates, La proteins have a novel domain arrangement and are linked to a distinct pre-tRNA processing pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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