FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development

Sanjeeb Kumar Sahu; Neha Tiwari; Abhijeet Pataskar; Yuan Zhuang; Marina Borisova; Mustafa Diken; Susanne Strand; Petra Beli; Vijay K. Tiwari

doi:10.1038/s41467-017-01366-x

Nature Communications (Nov 2017)

FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development

Sanjeeb Kumar Sahu,
Neha Tiwari,
Abhijeet Pataskar,
Yuan Zhuang,
Marina Borisova,
Mustafa Diken,
Susanne Strand,
Petra Beli,
Vijay K. Tiwari

Affiliations

Sanjeeb Kumar Sahu: Institute of Molecular Biology (IMB)
Neha Tiwari: Institute of Physiological Chemistry, University Medical Center, Johannes Gutenberg University
Abhijeet Pataskar: Institute of Molecular Biology (IMB)
Yuan Zhuang: Institute of Molecular Biology (IMB)
Marina Borisova: Institute of Molecular Biology (IMB)
Mustafa Diken: TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH
Susanne Strand: Department of Internal Medicine I, University Medical Center, Johannes Gutenberg University
Petra Beli: Institute of Molecular Biology (IMB)
Vijay K. Tiwari: Institute of Molecular Biology (IMB)

DOI: https://doi.org/10.1038/s41467-017-01366-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 18

Abstract

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Epithelial-to-mesenchymal transition (EMT) regulates both processes of organism development and changes in cell state causing disease. Here, the authors show that an E3 ubiquitin ligase, FBXO32, regulates EMT via CtBP1 and the transcriptional program, and also mediates cancer metastatic burden and neurogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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