A Preliminary Study on the Feasibility of Detecting Global Acute Cerebral Ischemia by the MIPS Method

Wei Zhuang; Wencai Pan; Lin Xu; Jingbo Chen; Jia Xu; Zelin Bai; Gen Li; Mingsheng Chen; Jian Sun; Mingxin Qin

doi:10.1109/ACCESS.2020.2973250

IEEE Access (Jan 2020)

A Preliminary Study on the Feasibility of Detecting Global Acute Cerebral Ischemia by the MIPS Method

Wei Zhuang,
Wencai Pan,
Lin Xu,
Jingbo Chen,
Jia Xu,
Zelin Bai,
Gen Li,
Mingsheng Chen,
Jian Sun,
Mingxin Qin

Affiliations

Wei Zhuang: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China
Wencai Pan: ORCiD; Department of Equipment Division, Xinqiao Hospital, Chongqing, China
Lin Xu: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China
Jingbo Chen: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China
Jia Xu: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China
Zelin Bai: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China
Gen Li: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China
Mingsheng Chen: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China
Jian Sun: ORCiD; Department of Neurosurgery, Southwest Hospital, Chongqing, China
Mingxin Qin: ORCiD; College of Biomedical Engineering, Army Medical University, Chongqing, China

DOI: https://doi.org/10.1109/ACCESS.2020.2973250
Journal volume & issue: Vol. 8
pp. 32290 – 32296

Abstract

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Acute cerebral ischemia is an important clinical disease that is usually detected by magnetic resonance imaging or computed tomography. The magnetic inductive phase shift (MIPS) is a new method for detecting cerebral diseases, which is non-invasive, miniaturized, and low-cost. A total of 25 rabbits were studied using a two-coil sensor with a 0.3-200 MHz frequency range, and all the subjects were measured for 1 hour. Based on the rabbit acute cerebral ischemia model, the rabbits were divided into unilateral ligation, bilateral ligation, and non-ligation groups. The results showed that the average MIPS values of the non-ligation, unilateral ligation, and bilateral ligation group were -0.195 ± 0.079°, -4.873 ± 1.042°, and -9.165 ± 2.862° respectively. MIPS distinguished different severities of cerebral ischemia in rabbits with statistical significance (p <; 0.05). Laser Doppler flowmetry (LDF) was used as the gold standard for collecting cerebral blood flow data. The strong correlation between the LDF measurements and the phase shift suggested that the phase shift reflects blood flow changes in the brain. Overall, these results suggest that the MIPS detection method has the potential to provide early detection of global cerebral ischemia. Furthermore, this method effectively distinguished different severities of cerebral ischemia.

Published in IEEE Access

ISSN: 2169-3536 (Online)
Publisher: IEEE
Country of publisher: United States
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering
Website: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=6287639

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