Frontiers in Cardiovascular Medicine (Jun 2023)
Decreased ventricular systolic function in chemotherapy-naive patients with acute myeloid leukemia: a three-dimensional speckle-tracking echocardiography study
- Yichan Zhang,
- Yichan Zhang,
- Yichan Zhang,
- Yuting Tan,
- Yuting Tan,
- Yuting Tan,
- Tianshu Liu,
- Tianshu Liu,
- Tianshu Liu,
- Yanan Fu,
- Yanan Fu,
- Yanan Fu,
- Yixia Lin,
- Yixia Lin,
- Yixia Lin,
- Jiawei Shi,
- Jiawei Shi,
- Jiawei Shi,
- Yanting Zhang,
- Yanting Zhang,
- Yanting Zhang,
- Wenhui Deng,
- Wenhui Deng,
- Wenhui Deng,
- Shukun He,
- Shukun He,
- Shukun He,
- Yali Yang,
- Yali Yang,
- Yali Yang,
- Qing Lv,
- Qing Lv,
- Qing Lv,
- Li Zhang,
- Li Zhang,
- Li Zhang,
- Mingxing Xie,
- Mingxing Xie,
- Mingxing Xie,
- Jing Wang,
- Jing Wang,
- Jing Wang
Affiliations
- Yichan Zhang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yichan Zhang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yichan Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yuting Tan
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yuting Tan
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yuting Tan
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Tianshu Liu
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Tianshu Liu
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Tianshu Liu
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yanan Fu
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yanan Fu
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yanan Fu
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yixia Lin
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yixia Lin
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yixia Lin
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Jiawei Shi
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jiawei Shi
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Jiawei Shi
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yanting Zhang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yanting Zhang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yanting Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Wenhui Deng
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Wenhui Deng
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Wenhui Deng
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Shukun He
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Shukun He
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Shukun He
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yali Yang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yali Yang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yali Yang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Qing Lv
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Qing Lv
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Qing Lv
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Li Zhang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Li Zhang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Li Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Mingxing Xie
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Mingxing Xie
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Mingxing Xie
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Jing Wang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jing Wang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Jing Wang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- DOI
- https://doi.org/10.3389/fcvm.2023.1140234
- Journal volume & issue
-
Vol. 10
Abstract
BackgroundThe relationship between acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) and cardiac function is not well established. This study aimed to evaluate whether AML patients exist early myocardial damages prior to chemotherapy and to investigate its association with cardiovascular biomarkers.MethodsConventional echocardiography and three-dimensional speckle-tracking strain analysis were performed prospectively in 72 acute leukemia (AL) patients before any chemotherapy therapy (of whom 44 were AML patients, 28 ALL patients). The results were compared with those from 58 control group matched for age and gender.ResultsThere were no significant differences in conventional biventricular systolic function parameters between AL patients and controls. The left ventricular global longitudinal strain (LVGLS) and right ventricular free wall longitudinal strain (RVFWLS) were significantly lower in AL patients (−23.0 ± 1.4% vs. −24.1 ± 1.3% and −27.9 ± 7.1% vs. −33.0 ± 4.6%, respectively, P < 0.001 for all). Compared with ALL patients, AML patients had lower LVGLS and RVFWLS (−22.7 ± 1.3% vs. −23.5 ± 1.6% and −26.2 ± 7.6% vs. −30.4 ± 5.5%, respectively, P < 0.05 for all). LVGLS was lower in ALL patients compared with controls (−23.5 ± 1.6% vs. −24.7 ± 1.4%, P < 0.05), however, there was no difference in right ventricular systolic function parameters between the two groups. LVGLS in AL patients was independently correlated with left ventricular ejection fraction (LVEF) and the absolute number of circulating lymphocytes.ConclusionsOur findings suggest that baseline myocardial systolic function is lower in AL patients than controls. AML patients had lower baseline LVGLS and RVFWLS than controls and ALL patients. The decreased LVGLS is correlated with LVEF and the absolute number of circulating lymphocytes.
Keywords
- acute myeloid leukemia
- three-dimensional speckle-tracking strain
- ventricular systolic function
- oncology cardiology, echocardiography