Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy

Smriti Prasad; Erkan Kalafat; Helena Blakeway; Rosemary Townsend; Pat O’Brien; Edward Morris; Tim Draycott; Shakila Thangaratinam; Kirsty Le Doare; Shamez Ladhani; Peter von Dadelszen; Laura A. Magee; Paul Heath; Asma Khalil

doi:10.1038/s41467-022-30052-w

Nature Communications (May 2022)

Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy

Smriti Prasad,
Erkan Kalafat,
Helena Blakeway,
Rosemary Townsend,
Pat O’Brien,
Edward Morris,
Tim Draycott,
Shakila Thangaratinam,
Kirsty Le Doare,
Shamez Ladhani,
Peter von Dadelszen,
Laura A. Magee,
Paul Heath,
Asma Khalil

Affiliations

Smriti Prasad: Fetal Medicine Unit, St George’s Hospital, St George’s University of London
Erkan Kalafat: Department of Statistics, Faculty of Arts and Sciences, Middle East Technical University
Helena Blakeway: Fetal Medicine Unit, St George’s Hospital, St George’s University of London
Rosemary Townsend: Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Pat O’Brien: The Royal College of Obstetricians and Gynaecologists
Edward Morris: The Royal College of Obstetricians and Gynaecologists
Tim Draycott: The Royal College of Obstetricians and Gynaecologists
Shakila Thangaratinam: Institute of Metabolism and Systems Research, WHO Collaborating Centre for Women’s Health, University of Birmingham
Kirsty Le Doare: Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George’s University of London
Shamez Ladhani: Immunisation and Countermeasures Division, Public Health England
Peter von Dadelszen: Institute of Women and Children’s Health, School of Life Course Sciences, King’s College London
Laura A. Magee: Institute of Women and Children’s Health, School of Life Course Sciences, King’s College London
Paul Heath: Paediatric Infectious Diseases Research Group and Vaccine Institute, Institute of Infection and Immunity, St George’s University of London
Asma Khalil: Fetal Medicine Unit, St George’s Hospital, St George’s University of London

DOI: https://doi.org/10.1038/s41467-022-30052-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

Read online

Pregnant women have been disproportionately under-vaccinated against COVID-19, partly because they were excluded from initial trials. This systematic review and meta-analysis supports efficacy of vaccination in pregnancy, and finds no evidence of adverse maternal or perinatal outcomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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