The Evaluation of the Newborn Patients with Diagnosis of the Culture-Proven Sepsis

Abstract

INTRODUCTION[|]Neonatal sepsis continues to be an important cause of morbidity and mortality in infants despite improvements in diagnosis and treatment. This study was planned to evaluate the demographic data, causative microorganisms and acute phase reactants at the time of diagnosis of blood culture positive sepsis in our neonatal intensive care unit.[¤]METHODS[|]We evaluated our patients diagnosed with blood culture positive sepsis in the neonatal intensive care unit during three years retrospectively. In this study, 131 patients whose clinical and laboratory findings were consistent with sepsis were included.[¤]RESULTS[|]The most common microorganism isolated from blood cultures that were taken at the time of diagnosis was S. aureus (n=36, 27.5%). Nineteen of them were methicillin-resistant S. aureus. Klebsiella species were isolated in 26 cases (19.8%) (K. pneumoniae, K. oxytoca and ESBL positive Klebsiella species in 13, 2 and 11 cases, respectively). Thrombocyte counts of our patients were statistically significantly lower on the first day of culture sampling compared to the fifth-day values (p<0.05), in contrast, CRP and mean platelet volume (MPV) values were significantly higher (p<0.05). According to our findings, on the first day of culture sampling, the CRP and mean of maximum CRP values of our patients with gram-positive sepsis were significantly lower than the values of our patients with gram-negative sepsis (p<0.05).[¤]DISCUSSION AND CONCLUSION[|]In this study, the most common microorganisms which cause sepsis in our neonatal intensive care unit were determined. We detected that the clinical findings and markers of sepsis differ depending on the type of the organism, whether gram-positive or gram-negative and the type of infection, whether it is nosocomial or not.[¤]

Keywords

• crp
• mean platelet volume (mpv); mortality; neonatal; sepsis.