Efficacy and Safety Study of Low-Molecular-Weight Heparin and Fondaparinux Sodium After Hip Arthroplasty: A Retrospective Cohort Study

Abstract

Abuduwupuer Haibier,1,2,* Alimujiang Yusufu,1,2,* Hang Lin,1,2 Aiben Kayierhan,1,2 Yimuran Abudukelimu,1,2 Tuerhongjiang Abudurexiti1,2 1Minimally Invasive Spine Surgery, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China; 2Xinjiang Medical University, Urumqi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tuerhongjiang Abudurexiti, Email [email protected]: Low molecular heparin(LMWH) and sodium sulfadiazine heparin(FPX) are commonly used to prevent deep vein thrombosis(DVT) after total hip arthroplasty(THA). In this study, we compared the role of these drugs in preventing DVT after THA.Methods: Patients who underwent unilateral THA at the Sixth Affiliated Hospital of Xinjiang Medical University from April 2020 to December 2022 were retrospectively analyzed for inclusion in this study. According to the anticoagulant drugs used, the patients were divided into LMWH group (n=106) and FPX group (n=97). Changes in perioperative coagulation-related indices, hemoglobin, blood loss And the postoperative complications.Results: The preoperative indexes of the two groups of patients, the difference was not statistically significant (P> 0.05); the indexes of Intraoperative blood loss, Visible blood loss, Hidden blood loss, and Total blood loss of the two groups of patients were compared, and the difference was not significant (P> 0.05); PT activity and INR in the LMWH group were significantly lower than those in the FPX group on the 1st and 5th postoperative days, and the differences were significant (P 0.05). The differences in blood transfusion rate and blood volume between the two groups were not significant (P> 0.05); the total hospitalization cost of the LMWH group was significantly lower than that of the FPX group, and the difference was significant (P 0.05).Conclusion: In this study, we found that the efficacy and safety of FPX and LMWH in preventing VTE after THA were basically the same, and the total cost of hospitalization in the LMWH group was significantly lower than that in the FPX group; however, due to the limited inclusion of the sample size, high-quality, large-sample, long-term follow-up clinical studies are necessary.Keywords: hip osteoarthritis, total Hip arthroplasty, low-molecular-weight heparin, fondaparinux sodium, coagulation indicator, thrombosis

Keywords

• hip osteoarthritis
• total hip arthroplasty
• low-molecular-weight heparin
• fondaparinux sodium
• coagulation indicator
• thrombosis