Simultaneous and stoichiometric purification of hundreds of oligonucleotides

Alessandro Pinto; Sherry X. Chen; David Yu Zhang

doi:10.1038/s41467-018-04870-w

Nature Communications (Jun 2018)

Simultaneous and stoichiometric purification of hundreds of oligonucleotides

Alessandro Pinto,
Sherry X. Chen,
David Yu Zhang

Affiliations

Alessandro Pinto: Department of Bioengineering, Rice University
Sherry X. Chen: Department of Bioengineering, Rice University
David Yu Zhang: Department of Bioengineering, Rice University

DOI: https://doi.org/10.1038/s41467-018-04870-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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Chemically synthesized DNA oligonucleotides (oligos) require purification to remove truncated species. Here, the authors developed a high-throughput method for oligo purification that also normalises the concentrations of the oligos in the final samples.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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