Nature Communications (Nov 2021)

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

  • Baptiste Lamarthée,
  • Armance Marchal,
  • Soëli Charbonnier,
  • Tifanie Blein,
  • Juliette Leon,
  • Emmanuel Martin,
  • Lucas Rabaux,
  • Katrin Vogt,
  • Matthias Titeux,
  • Marianne Delville,
  • Hélène Vinçon,
  • Emmanuelle Six,
  • Nicolas Pallet,
  • David Michonneau,
  • Dany Anglicheau,
  • Christophe Legendre,
  • Jean-Luc Taupin,
  • Ivan Nemazanyy,
  • Birgit Sawitzki,
  • Sylvain Latour,
  • Marina Cavazzana,
  • Isabelle André,
  • Julien Zuber

DOI
https://doi.org/10.1038/s41467-021-26844-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.