Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives

Yao Tian; Xiubin Bu; Yuanrui Chen; Luohe Wang; Junnan E; Jing Zeng; Hao Xu; Aihong Han; Xiaobo Yang; Zhen Zhao

doi:10.3390/catal13121502

Catalysts (Dec 2023)

Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives

Yao Tian,
Xiubin Bu,
Yuanrui Chen,
Luohe Wang,
Junnan E,
Jing Zeng,
Hao Xu,
Aihong Han,
Xiaobo Yang,
Zhen Zhao

Affiliations

Yao Tian: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Xiubin Bu: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Yuanrui Chen: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Luohe Wang: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Junnan E: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Jing Zeng: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Hao Xu: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
Aihong Han: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Xiaobo Yang: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China
Zhen Zhao: Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China

DOI: https://doi.org/10.3390/catal13121502
Journal volume & issue: Vol. 13, no. 12
p. 1502

Abstract

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The glycine motif is widely prevalent in bioactive peptides. Thus, the direct and precise modification of glycine derivatives has attracted significant attention over the past few decades. Among various protocols for the modification of glycine derivatives, the visible-light-driven direct α-C(sp3)–H bond functionalization of glycine derivatives has emerged as a powerful tool to achieve this objective, owing to its merits in atom economy, selectivity, reaction simplicity, and sustainability. This review summarizes the recent advancements in visible-light-driven direct α-C(sp3)–H bond functionalization of glycine derivatives. The contents of this review are organized based on the photocatalysts employed and the various reaction modes in the functionalization process. The mechanism, the challenges encountered, and future trends are also discussed, enabling readers to understand the current developmental status in this field.

Published in Catalysts

ISSN: 2073-4344 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology; Science: Chemistry
Website: https://www.mdpi.com/journal/catalysts

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