Nature Communications (Mar 2019)

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

  • Sindhuja Sridharan,
  • Nils Kurzawa,
  • Thilo Werner,
  • Ina Günthner,
  • Dominic Helm,
  • Wolfgang Huber,
  • Marcus Bantscheff,
  • Mikhail M. Savitski

DOI
https://doi.org/10.1038/s41467-019-09107-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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ATP can function as a biological hydrotrope, but its global effects on protein solubility have not yet been characterized. Here, the authors quantify the effect of ATP on the thermal stability and solubility of the cellular proteome, providing insights into protein solubility regulation by ATP.