Human midbrain organoids: a powerful tool for advanced Parkinson’s disease modeling and therapy exploration

Xin Cui; Xinwei Li; Huimin Zheng; Yun Su; Shuyu Zhang; Mengjie Li; Xiaoyan Hao; Shuo Zhang; Zhengwei Hu; Zongping Xia; Changhe Shi; Yuming Xu; Chengyuan Mao

doi:10.1038/s41531-024-00799-8

npj Parkinson's Disease (Oct 2024)

Human midbrain organoids: a powerful tool for advanced Parkinson’s disease modeling and therapy exploration

Xin Cui,
Xinwei Li,
Huimin Zheng,
Yun Su,
Shuyu Zhang,
Mengjie Li,
Xiaoyan Hao,
Shuo Zhang,
Zhengwei Hu,
Zongping Xia,
Changhe Shi,
Yuming Xu,
Chengyuan Mao

Affiliations

Xin Cui: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Xinwei Li: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Huimin Zheng: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Yun Su: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Shuyu Zhang: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Mengjie Li: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Xiaoyan Hao: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Shuo Zhang: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Zhengwei Hu: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Zongping Xia: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Changhe Shi: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Yuming Xu: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University
Chengyuan Mao: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University

DOI: https://doi.org/10.1038/s41531-024-00799-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Abstract Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons in the substantia nigra. Despite progress, the pathogenesis remains unclear. Human midbrain organoids (hMLOs) have emerged as a promising model for studying PD, drug screening, and potential treatments. This review discusses the development of hMLOs, their application in PD research, and current challenges in organoid construction, highlighting possible optimization strategies.

Published in npj Parkinson's Disease

ISSN: 2373-8057 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.nature.com/npjparkd/

About the journal