Journal of Indian Academy of Oral Medicine and Radiology (Jan 2009)

Papillon-Lefevre syndrome

  • S Sujatha,
  • Namita Raghav

DOI
https://doi.org/10.4103/0972-1363.57774
Journal volume & issue
Vol. 21, no. 1
pp. 21 – 24

Abstract

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Papillon-Lefevre syndrome (PLS) is a very rare syndrome of autosomal recessive inheritance characterized by palmar-plantar hyperkeratosis and early onset of a severe destructive periodontitis, leading to premature loss of both primary and permanent dentitions. The palmar-plantar keratoderma typically has its onset between the ages of 1 and 4 years and severe periodontitis starts at the age of 3 or 4 years. The exact pathogenesis of these clinical events remains mainly speculative. An early diagnosis of the syndrome can help preserve the teeth by early institution of treatment, using a multidisciplinary approach. This paper describes a case of PLS with classic clinical features and briefly reviews the relevant literature.

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