EClinicalMedicine (Jan 2023)
Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort studyResearch in context
- Byorn W.L. Tan,
- Bryce W.Q. Tan,
- Amelia L.M. Tan,
- Emily R. Schriver,
- Alba Gutiérrez-Sacristán,
- Priyam Das,
- William Yuan,
- Meghan R. Hutch,
- Noelia García Barrio,
- Miguel Pedrera Jimenez,
- Noor Abu-el-rub,
- Michele Morris,
- Bertrand Moal,
- Guillaume Verdy,
- Kelly Cho,
- Yuk-Lam Ho,
- Lav P. Patel,
- Arianna Dagliati,
- Antoine Neuraz,
- Jeffrey G. Klann,
- Andrew M. South,
- Shyam Visweswaran,
- David A. Hanauer,
- Sarah E. Maidlow,
- Mei Liu,
- Danielle L. Mowery,
- Ashley Batugo,
- Adeline Makoudjou,
- Patric Tippmann,
- Daniela Zöller,
- Gabriel A. Brat,
- Yuan Luo,
- Paul Avillach,
- Riccardo Bellazzi,
- Luca Chiovato,
- Alberto Malovini,
- Valentina Tibollo,
- Malarkodi Jebathilagam Samayamuthu,
- Pablo Serrano Balazote,
- Zongqi Xia,
- Ne Hooi Will Loh,
- Lorenzo Chiudinelli,
- Clara-Lea Bonzel,
- Chuan Hong,
- Harrison G. Zhang,
- Griffin M. Weber,
- Isaac S. Kohane,
- Tianxi Cai,
- Gilbert S. Omenn,
- John H. Holmes,
- Kee Yuan Ngiam,
- James R. Aaron,
- Giuseppe Agapito,
- Adem Albayrak,
- Giuseppe Albi,
- Mario Alessiani,
- Anna Alloni,
- Danilo F. Amendola,
- François Angoulvant,
- Li L.L.J. Anthony,
- Bruce J. Aronow,
- Fatima Ashraf,
- Andrew Atz,
- Paul Avillach,
- Vidul Ayakulangara Panickan,
- Paula S. Azevedo,
- James Balshi,
- Ashley Batugo,
- Brett K. Beaulieu-Jones,
- Brendin R. Beaulieu-Jones,
- Douglas S. Bell,
- Antonio Bellasi,
- Riccardo Bellazzi,
- Vincent Benoit,
- Michele Beraghi,
- José Luis Bernal-Sobrino,
- Mélodie Bernaux,
- Romain Bey,
- Surbhi Bhatnagar,
- Alvar Blanco-Martínez,
- Martin Boeker,
- Clara-Lea Bonzel,
- John Booth,
- Silvano Bosari,
- Florence T. Bourgeois,
- Robert L. Bradford,
- Gabriel A. Brat,
- Stéphane Bréant,
- Nicholas W. Brown,
- Raffaele Bruno,
- William A. Bryant,
- Mauro Bucalo,
- Emily Bucholz,
- Anita Burgun,
- Tianxi Cai,
- Mario Cannataro,
- Aldo Carmona,
- Anna Maria Cattelan,
- Charlotte Caucheteux,
- Julien Champ,
- Jin Chen,
- Krista Y. Chen,
- Luca Chiovato,
- Lorenzo Chiudinelli,
- Kelly Cho,
- James J. Cimino,
- Tiago K. Colicchio,
- Sylvie Cormont,
- Sébastien Cossin,
- Jean B. Craig,
- Juan Luis Cruz-Bermúdez,
- Jaime Cruz-Rojo,
- Arianna Dagliati,
- Mohamad Daniar,
- Christel Daniel,
- Priyam Das,
- Batsal Devkota,
- Audrey Dionne,
- Rui Duan,
- Julien Dubiel,
- Scott L. DuVall,
- Loic Esteve,
- Hossein Estiri,
- Shirley Fan,
- Robert W. Follett,
- Thomas Ganslandt,
- Noelia García-Barrio,
- Lana X. Garmire,
- Nils Gehlenborg,
- Emily J. Getzen,
- Alon Geva,
- Tomás González González,
- Tobias Gradinger,
- Alexandre Gramfort,
- Romain Griffier,
- Nicolas Griffon,
- Olivier Grisel,
- Alba Gutiérrez-Sacristán,
- Pietro H. Guzzi,
- Larry Han,
- David A. Hanauer,
- Christian Haverkamp,
- Derek Y. Hazard,
- Bing He,
- Darren W. Henderson,
- Martin Hilka,
- Yuk-Lam Ho,
- John H. Holmes,
- Jacqueline P. Honerlaw,
- Chuan Hong,
- Kenneth M. Huling,
- Meghan R. Hutch,
- Richard W. Issitt,
- Anne Sophie Jannot,
- Vianney Jouhet,
- Ramakanth Kavuluru,
- Mark S. Keller,
- Chris J. Kennedy,
- Kate F. Kernan,
- Daniel A. Key,
- Katie Kirchoff,
- Jeffrey G. Klann,
- Isaac S. Kohane,
- Ian D. Krantz,
- Detlef Kraska,
- Ashok K. Krishnamurthy,
- Sehi L'Yi,
- Trang T. Le,
- Judith Leblanc,
- Guillaume Lemaitre,
- Leslie Lenert,
- Damien Leprovost,
- Molei Liu,
- Ne Hooi Will Loh,
- Qi Long,
- Sara Lozano-Zahonero,
- Yuan Luo,
- Kristine E. Lynch,
- Sadiqa Mahmood,
- Sarah E. Maidlow,
- Adeline Makoudjou,
- Simran Makwana,
- Alberto Malovini,
- Kenneth D. Mandl,
- Chengsheng Mao,
- Anupama Maram,
- Monika Maripuri,
- Patricia Martel,
- Marcelo R. Martins,
- Jayson S. Marwaha,
- Aaron J. Masino,
- Maria Mazzitelli,
- Diego R. Mazzotti,
- Arthur Mensch,
- Marianna Milano,
- Marcos F. Minicucci,
- Bertrand Moal,
- Taha Mohseni Ahooyi,
- Jason H. Moore,
- Cinta Moraleda,
- Jeffrey S. Morris,
- Michele Morris,
- Karyn L. Moshal,
- Sajad Mousavi,
- Danielle L. Mowery,
- Douglas A. Murad,
- Shawn N. Murphy,
- Thomas P. Naughton,
- Carlos Tadeu Breda Neto,
- Antoine Neuraz,
- Jane Newburger,
- Kee Yuan Ngiam,
- Wanjiku F.M. Njoroge,
- James B. Norman,
- Jihad Obeid,
- Marina P. Okoshi,
- Karen L. Olson,
- Gilbert S. Omenn,
- Nina Orlova,
- Brian D. Ostasiewski,
- Nathan P. Palmer,
- Nicolas Paris,
- Lav P. Patel,
- Miguel Pedrera-Jiménez,
- Ashley C. Pfaff,
- Emily R. Pfaff,
- Danielle Pillion,
- Sara Pizzimenti,
- Tanu Priya,
- Hans U. Prokosch,
- Robson A. Prudente,
- Andrea Prunotto,
- Víctor Quirós-González,
- Rachel B. Ramoni,
- Maryna Raskin,
- Siegbert Rieg,
- Gustavo Roig-Domínguez,
- Pablo Rojo,
- Paula Rubio-Mayo,
- Paolo Sacchi,
- Carlos Sáez,
- Elisa Salamanca,
- Malarkodi Jebathilagam Samayamuthu,
- L. Nelson Sanchez-Pinto,
- Arnaud Sandrin,
- Nandhini Santhanam,
- Janaina C.C. Santos,
- Fernando J. Sanz Vidorreta,
- Maria Savino,
- Emily R. Schriver,
- Petra Schubert,
- Juergen Schuettler,
- Luigia Scudeller,
- Neil J. Sebire,
- Pablo Serrano-Balazote,
- Patricia Serre,
- Arnaud Serret-Larmande,
- Mohsin Shah,
- Zahra Shakeri Hossein Abad,
- Domenick Silvio,
- Piotr Sliz,
- Jiyeon Son,
- Charles Sonday,
- Andrew M. South,
- Francesca Sperotto,
- Anastasia Spiridou,
- Zachary H. Strasser,
- Amelia L.M. Tan,
- Bryce W.Q. Tan,
- Byorn W.L. Tan,
- Suzana E. Tanni,
- Deanne M. Taylor,
- Ana I. Terriza-Torres,
- Valentina Tibollo,
- Patric Tippmann,
- Emma M.S. Toh,
- Carlo Torti,
- Enrico M. Trecarichi,
- Andrew K. Vallejos,
- Gael Varoquaux,
- Margaret E. Vella,
- Guillaume Verdy,
- Jill-Jênn Vie,
- Shyam Visweswaran,
- Michele Vitacca,
- Kavishwar B. Wagholikar,
- Lemuel R. Waitman,
- Xuan Wang,
- Demian Wassermann,
- Griffin M. Weber,
- Martin Wolkewitz,
- Scott Wong,
- Zongqi Xia,
- Xin Xiong,
- Ye Ye,
- Nadir Yehya,
- William Yuan,
- Joany M. Zachariasse,
- Janet J. Zahner,
- Alberto Zambelli,
- Harrison G. Zhang,
- Daniela Zöller,
- Valentina Zuccaro,
- Chiara Zucco
Affiliations
- Byorn W.L. Tan
- Department of Medicine, National University Hospital, 1E Kent Ridge Road, NUHS Tower Block Level 10, Singapore 119228
- Bryce W.Q. Tan
- Department of Medicine, National University Hospital, 1E Kent Ridge Road, NUHS Tower Block Level 10, Singapore 119228
- Amelia L.M. Tan
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Emily R. Schriver
- Data Analytics Center, University of Pennsylvania Health System, 3600 Civic Center Boulevard, Philadelphia, PA 19104, USA
- Alba Gutiérrez-Sacristán
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Priyam Das
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- William Yuan
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Meghan R. Hutch
- Department of Preventive Medicine, Northwestern University, 750 North Lake Shore Drive, Chicago, IL 60611, USA
- Noelia García Barrio
- Department of Health Informatics, Hospital Universitario 12 de Octubre, Av. de Córdoba, s/n 28041 Madrid, Spain
- Miguel Pedrera Jimenez
- Department of Health Informatics, Hospital Universitario 12 de Octubre, Av. de Córdoba, s/n 28041 Madrid, Spain
- Noor Abu-el-rub
- Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
- Michele Morris
- Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, Pittsburgh, PA 15206, USA
- Bertrand Moal
- IAM Unit, Bordeaux University Hospital, Place Amélie Rabat Léon, 33076 Bordeaux, France
- Guillaume Verdy
- IAM Unit, Bordeaux University Hospital, Place Amélie Rabat Léon, 33076 Bordeaux, France
- Kelly Cho
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, 2 Avenue De Lafayette, Boston, MA 02130, USA
- Yuk-Lam Ho
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, 2 Avenue De Lafayette, Boston, MA 02130, USA
- Lav P. Patel
- Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
- Arianna Dagliati
- Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy, Via Ferrata 5, 27100 Pavia, Italy
- Antoine Neuraz
- Department of Biomedical Informatics, Hôpital Necker-Enfants Malade, Assistance Publique Hôpitaux de Paris, University of Paris, 149 Rue de Sèvres, 75015 Paris, France
- Jeffrey G. Klann
- Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
- Andrew M. South
- Department of Pediatrics-Section of Nephrology, Brenner Children's Hospital, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
- Shyam Visweswaran
- Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, Pittsburgh, PA 15206, USA
- David A. Hanauer
- Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA, 100-107 NCRC, 2800 Plymouth Road, Ann Arbor, MI 48109, USA
- Sarah E. Maidlow
- Michigan Institute for Clinical and Health Research (MICHR) Informatics, University of Michigan, NCRC Bldg 400, 2800 Plymouth Road, Ann Arbor, MI, United States
- Mei Liu
- Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
- Danielle L. Mowery
- Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, 3700 Hamilton Walk, Richards Hall, A202, Philadelphia, PA 19104, USA
- Ashley Batugo
- Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, 401 Blockley Hall 423 Guardian Drive Philadelphia, PA 19104, USA
- Adeline Makoudjou
- Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Zinkmattenstraße 6a, DE79108 Freiburg, Germany
- Patric Tippmann
- Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Zinkmattenstraße 6a, DE79108 Freiburg, Germany
- Daniela Zöller
- Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Zinkmattenstraße 6a, DE79108 Freiburg, Germany
- Gabriel A. Brat
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Yuan Luo
- Department of Preventive Medicine, Northwestern University, 750 North Lake Shore Drive, Chicago, IL 60611, USA
- Paul Avillach
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Riccardo Bellazzi
- Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy, Via Ferrata 5, 27100 Pavia, Italy
- Luca Chiovato
- Unit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Via Maugeri 4, 27100 Pavia, Italy
- Alberto Malovini
- Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy., Via Maugeri 4, 27100 Pavia, Italy
- Valentina Tibollo
- Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy., Via Maugeri 4, 27100 Pavia, Italy
- Malarkodi Jebathilagam Samayamuthu
- Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, Pittsburgh, PA 15206, USA
- Pablo Serrano Balazote
- Department of Health Informatics, Hospital Universitario 12 de Octubre, Av. de Córdoba, s/n 28041 Madrid, Spain
- Zongqi Xia
- Department of Neurology, University of Pittsburgh, 3501 5th Avenue, BST-3 Suite 7014, Pittsburgh, PA 15260, USA
- Ne Hooi Will Loh
- Department of Anaesthesia, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074
- Lorenzo Chiudinelli
- UOC Ricerca, Innovazione e Brand reputation, ASST Papa Giovanni XXIII, Bergamo, P.zza OMS 1 - 24127 Bergamo, Italy
- Clara-Lea Bonzel
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Chuan Hong
- Department of Biostatistics and Bioinformatics, Duke University, 2424 Erwin Road, Durham, NC, United States; Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Harrison G. Zhang
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Griffin M. Weber
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Isaac S. Kohane
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Tianxi Cai
- Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA
- Gilbert S. Omenn
- Department of Computational Medicine & Bioinformatics, University of Michigan, 2017B Palmer Commons, 100 Washtenaw, Ann Arbor, MI 48109-2218
- John H. Holmes
- Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, 3700 Hamilton Walk, Richards Hall, A202, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, 401 Blockley Hall 423 Guardian Drive Philadelphia, PA 19104, USA
- Kee Yuan Ngiam
- Department of Biomedical Informatics, WiSDM, National University Health Systems Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 8, Singapore 119228; Corresponding author. Department of Biomedical Informatics, WiSDM, National University Health Systems Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 8, Singapore 119228.
- James R. Aaron
- Giuseppe Agapito
- Adem Albayrak
- Giuseppe Albi
- Mario Alessiani
- Anna Alloni
- Danilo F. Amendola
- François Angoulvant
- Li L.L.J. Anthony
- Bruce J. Aronow
- Fatima Ashraf
- Andrew Atz
- Paul Avillach
- Vidul Ayakulangara Panickan
- Paula S. Azevedo
- James Balshi
- Ashley Batugo
- Brett K. Beaulieu-Jones
- Brendin R. Beaulieu-Jones
- Douglas S. Bell
- Antonio Bellasi
- Riccardo Bellazzi
- Vincent Benoit
- Michele Beraghi
- José Luis Bernal-Sobrino
- Mélodie Bernaux
- Romain Bey
- Surbhi Bhatnagar
- Alvar Blanco-Martínez
- Martin Boeker
- Clara-Lea Bonzel
- John Booth
- Silvano Bosari
- Florence T. Bourgeois
- Robert L. Bradford
- Gabriel A. Brat
- Stéphane Bréant
- Nicholas W. Brown
- Raffaele Bruno
- William A. Bryant
- Mauro Bucalo
- Emily Bucholz
- Anita Burgun
- Tianxi Cai
- Mario Cannataro
- Aldo Carmona
- Anna Maria Cattelan
- Charlotte Caucheteux
- Julien Champ
- Jin Chen
- Krista Y. Chen
- Luca Chiovato
- Lorenzo Chiudinelli
- Kelly Cho
- James J. Cimino
- Tiago K. Colicchio
- Sylvie Cormont
- Sébastien Cossin
- Jean B. Craig
- Juan Luis Cruz-Bermúdez
- Jaime Cruz-Rojo
- Arianna Dagliati
- Mohamad Daniar
- Christel Daniel
- Priyam Das
- Batsal Devkota
- Audrey Dionne
- Rui Duan
- Julien Dubiel
- Scott L. DuVall
- Loic Esteve
- Hossein Estiri
- Shirley Fan
- Robert W. Follett
- Thomas Ganslandt
- Noelia García-Barrio
- Lana X. Garmire
- Nils Gehlenborg
- Emily J. Getzen
- Alon Geva
- Tomás González González
- Tobias Gradinger
- Alexandre Gramfort
- Romain Griffier
- Nicolas Griffon
- Olivier Grisel
- Alba Gutiérrez-Sacristán
- Pietro H. Guzzi
- Larry Han
- David A. Hanauer
- Christian Haverkamp
- Derek Y. Hazard
- Bing He
- Darren W. Henderson
- Martin Hilka
- Yuk-Lam Ho
- John H. Holmes
- Jacqueline P. Honerlaw
- Chuan Hong
- Kenneth M. Huling
- Meghan R. Hutch
- Richard W. Issitt
- Anne Sophie Jannot
- Vianney Jouhet
- Ramakanth Kavuluru
- Mark S. Keller
- Chris J. Kennedy
- Kate F. Kernan
- Daniel A. Key
- Katie Kirchoff
- Jeffrey G. Klann
- Isaac S. Kohane
- Ian D. Krantz
- Detlef Kraska
- Ashok K. Krishnamurthy
- Sehi L'Yi
- Trang T. Le
- Judith Leblanc
- Guillaume Lemaitre
- Leslie Lenert
- Damien Leprovost
- Molei Liu
- Ne Hooi Will Loh
- Qi Long
- Sara Lozano-Zahonero
- Yuan Luo
- Kristine E. Lynch
- Sadiqa Mahmood
- Sarah E. Maidlow
- Adeline Makoudjou
- Simran Makwana
- Alberto Malovini
- Kenneth D. Mandl
- Chengsheng Mao
- Anupama Maram
- Monika Maripuri
- Patricia Martel
- Marcelo R. Martins
- Jayson S. Marwaha
- Aaron J. Masino
- Maria Mazzitelli
- Diego R. Mazzotti
- Arthur Mensch
- Marianna Milano
- Marcos F. Minicucci
- Bertrand Moal
- Taha Mohseni Ahooyi
- Jason H. Moore
- Cinta Moraleda
- Jeffrey S. Morris
- Michele Morris
- Karyn L. Moshal
- Sajad Mousavi
- Danielle L. Mowery
- Douglas A. Murad
- Shawn N. Murphy
- Thomas P. Naughton
- Carlos Tadeu Breda Neto
- Antoine Neuraz
- Jane Newburger
- Kee Yuan Ngiam
- Wanjiku F.M. Njoroge
- James B. Norman
- Jihad Obeid
- Marina P. Okoshi
- Karen L. Olson
- Gilbert S. Omenn
- Nina Orlova
- Brian D. Ostasiewski
- Nathan P. Palmer
- Nicolas Paris
- Lav P. Patel
- Miguel Pedrera-Jiménez
- Ashley C. Pfaff
- Emily R. Pfaff
- Danielle Pillion
- Sara Pizzimenti
- Tanu Priya
- Hans U. Prokosch
- Robson A. Prudente
- Andrea Prunotto
- Víctor Quirós-González
- Rachel B. Ramoni
- Maryna Raskin
- Siegbert Rieg
- Gustavo Roig-Domínguez
- Pablo Rojo
- Paula Rubio-Mayo
- Paolo Sacchi
- Carlos Sáez
- Elisa Salamanca
- Malarkodi Jebathilagam Samayamuthu
- L. Nelson Sanchez-Pinto
- Arnaud Sandrin
- Nandhini Santhanam
- Janaina C.C. Santos
- Fernando J. Sanz Vidorreta
- Maria Savino
- Emily R. Schriver
- Petra Schubert
- Juergen Schuettler
- Luigia Scudeller
- Neil J. Sebire
- Pablo Serrano-Balazote
- Patricia Serre
- Arnaud Serret-Larmande
- Mohsin Shah
- Zahra Shakeri Hossein Abad
- Domenick Silvio
- Piotr Sliz
- Jiyeon Son
- Charles Sonday
- Andrew M. South
- Francesca Sperotto
- Anastasia Spiridou
- Zachary H. Strasser
- Amelia L.M. Tan
- Bryce W.Q. Tan
- Byorn W.L. Tan
- Suzana E. Tanni
- Deanne M. Taylor
- Ana I. Terriza-Torres
- Valentina Tibollo
- Patric Tippmann
- Emma M.S. Toh
- Carlo Torti
- Enrico M. Trecarichi
- Andrew K. Vallejos
- Gael Varoquaux
- Margaret E. Vella
- Guillaume Verdy
- Jill-Jênn Vie
- Shyam Visweswaran
- Michele Vitacca
- Kavishwar B. Wagholikar
- Lemuel R. Waitman
- Xuan Wang
- Demian Wassermann
- Griffin M. Weber
- Martin Wolkewitz
- Scott Wong
- Zongqi Xia
- Xin Xiong
- Ye Ye
- Nadir Yehya
- William Yuan
- Joany M. Zachariasse
- Janet J. Zahner
- Alberto Zambelli
- Harrison G. Zhang
- Daniela Zöller
- Valentina Zuccaro
- Chiara Zucco
- Journal volume & issue
-
Vol. 55
p. 101724
Abstract
Summary: Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32–1.67) and 365 days (RR 1.54, 95%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section.
