Health and Liver Diagnostic Markers Influencing Glycemia in Subjects with Prediabetes: Preview Study
Omar Ramos-Lopez,
Diego Martinez-Urbistondo,
Santiago Navas-Carretero,
Ruixin Zhu,
Maija Huttunen-Lenz,
Gareth Stratton,
Teodora Handjieva-Darlenska,
Svetoslav Handjiev,
Jouko Ensio Sundvall,
Marta P. Silvestre,
Elli Jalo,
Kirsi H. Pietiläinen,
Tanja C. Adam,
Margriet Westerterp-Plantenga,
Elizabeth Simpson,
Ian MacDonald,
Moira A. Taylor,
Sally D. Poppitt,
Wolfgang Schlicht,
Jennie Brand-Miller,
Mikael Fogelholm,
Anne Raben,
J. Alfredo Martinez
Affiliations
Omar Ramos-Lopez
Medicine and Psychology School, Autonomous University of Baja California, Tijuana 22390, Baja California, Mexico
Diego Martinez-Urbistondo
Internal Medicine Department, Clinica Universidad de Navarra, 28027 Madrid, Spain
Santiago Navas-Carretero
Centre for Nutrition Research, Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31009 Pamplona, Spain
Ruixin Zhu
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2200 Copenhagen, Denmark
Maija Huttunen-Lenz
Institute for Nursing Science, University of Education Schwäbisch Gmünd, 73525 Schwäbisch Gmünd, Germany
Gareth Stratton
Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea SA1 8EN, UK
Teodora Handjieva-Darlenska
Department of Pharmacology and Toxicology, Medical University of Sofia, 1000 Sofia, Bulgaria
Svetoslav Handjiev
Department of Pharmacology and Toxicology, Medical University of Sofia, 1000 Sofia, Bulgaria
Jouko Ensio Sundvall
Finnish Institute for Health and Welfare, 00271 Helsinki, Finland
Marta P. Silvestre
Human Nutrition Unit, Department of Medicine, School of Biological Sciences, University of Auckland, Auckland 1024, New Zealand
Elli Jalo
Department of Food and Nutrition, University of Helsinki, 00014 Helsinki, Finland
Kirsi H. Pietiläinen
Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
Tanja C. Adam
Department of Nutrition and Movement Sciences, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 Maastricht, The Netherlands
Margriet Westerterp-Plantenga
Department of Nutrition and Movement Sciences, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 Maastricht, The Netherlands
Elizabeth Simpson
MRC/ARUK Centre for Musculoskeletal Ageing Research, ARUK Centre for Sport, Exercise and Osteoarthritis, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham DE22 3DT, UK
Ian MacDonald
MRC/ARUK Centre for Musculoskeletal Ageing Research, ARUK Centre for Sport, Exercise and Osteoarthritis, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham DE22 3DT, UK
Moira A. Taylor
NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust and University of Nottingham, The David Greenfield Human Physiology Unit, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG1 5DU, UK
Sally D. Poppitt
Human Nutrition Unit, Department of Medicine, School of Biological Sciences, University of Auckland, Auckland 1024, New Zealand
Wolfgang Schlicht
Exercise and Health Sciences, University of Stuttgart, 70569 Stuttgart, Germany
Jennie Brand-Miller
School of Life and Environmental Sciences and Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia
Mikael Fogelholm
Department of Food and Nutrition, University of Helsinki, 00014 Helsinki, Finland
Anne Raben
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2200 Copenhagen, Denmark
J. Alfredo Martinez
Centre for Nutrition Research, Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, 31009 Pamplona, Spain
Introduction: Glucose homeostasis may be dependent on liver conditions and influence health-related markers and quality of life (QoL) objective measurements. This study aimed to analyze the interactions of glycemia with liver and health status in a prediabetic population. Subjects and methods: This study included 2220 overweight/obese prediabetics from the multinational PREVIEW project. Anthropometrics; clinical, metabolic and other health-related markers; and QoL variables were analyzed. Univariate and multilinear-adjusted regression models were run to explain the interrelationships and effect modification between glycemia, health-related QoL (applying SF-12) and metabolic/liver health (using the HSI, a putative marker of fatty liver). Results: Relevant age/sex interactions were found concerning the levels of insulin, HOMA-IR, C peptide and transaminases in this prediabetic population. Multivariate models identified age, sex, glucose, WC and QoL as important predictors of HSI variability (adj. R value = 0.1393, p p p = 0.011) when the data were analyzed when comparing lower glycemia vs. higher glycemia in prediabetics. Indeed, an effect modification was featured depending on the glycemia levels concerning the QoL and HSI worsening. Conclusion: Glycemia associations with the QoL status and liver metabolism markers were evidenced, with clinical implications for diabetes and liver disease precision management given the modification of the QoL outcomes depending on the liver status and glycemia concentrations. Notably, independent associations of circulating glucose with age, sex, adiposity, inflammation and C peptide levels were found.
