Nature Communications (Sep 2017)
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation
- Jinglin L. Xie,
- Longguang Qin,
- Zhengqiang Miao,
- Ben T. Grys,
- Jacinto De La Cruz Diaz,
- Kenneth Ting,
- Jonathan R. Krieger,
- Jiefei Tong,
- Kaeling Tan,
- Michelle D. Leach,
- Troy Ketela,
- Michael F. Moran,
- Damian J. Krysan,
- Charles Boone,
- Brenda J. Andrews,
- Anna Selmecki,
- Koon Ho Wong,
- Nicole Robbins,
- Leah E. Cowen
Affiliations
- Jinglin L. Xie
- Department of Molecular Genetics, University of Toronto
- Longguang Qin
- Faculty of Health Sciences, University of Macau
- Zhengqiang Miao
- Faculty of Health Sciences, University of Macau
- Ben T. Grys
- Department of Molecular Genetics, University of Toronto
- Jacinto De La Cruz Diaz
- Department of Microbiology and Immunology, University of Rochester
- Kenneth Ting
- Department of Molecular Genetics, University of Toronto
- Jonathan R. Krieger
- The Hospital for Sick Children, SPARC Biocentre
- Jiefei Tong
- The Hospital for Sick Children, Program in Cell Biology, Peter Gilgan Centre for Research and Learning
- Kaeling Tan
- Faculty of Health Sciences, University of Macau
- Michelle D. Leach
- Department of Molecular Genetics, University of Toronto
- Troy Ketela
- Department of Molecular Genetics, University of Toronto
- Michael F. Moran
- Department of Molecular Genetics, University of Toronto
- Damian J. Krysan
- Department of Microbiology and Immunology, University of Rochester
- Charles Boone
- Department of Molecular Genetics, University of Toronto
- Brenda J. Andrews
- Department of Molecular Genetics, University of Toronto
- Anna Selmecki
- Department of Medical Microbiology and Immunology, Creighton University School of Medicine
- Koon Ho Wong
- Faculty of Health Sciences, University of Macau
- Nicole Robbins
- Department of Molecular Genetics, University of Toronto
- Leah E. Cowen
- Department of Molecular Genetics, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-017-00547-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Cas5 is a transcriptional regulator of responses to cell wall stress in the fungal pathogen Candida albicans. Here, Xie et al. show that Cas5 also modulates cell cycle dynamics and responses to antifungal drugs.
