Nature Communications (Jul 2018)

Patterns of genomic evolution in advanced melanoma

  • E. Birkeland,
  • S. Zhang,
  • D. Poduval,
  • J. Geisler,
  • S. Nakken,
  • D. Vodak,
  • L. A. Meza-Zepeda,
  • E. Hovig,
  • O. Myklebost,
  • S. Knappskog,
  • P. E. Lønning

DOI
https://doi.org/10.1038/s41467-018-05063-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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As melanoma progresses, it evolves. Here, in advanced melanoma the authors study genomic evolution, highlighting trunk mutations dominated by the ultraviolet damage signature, common late truncal whole-genome duplication events, as well as selective copy number gain of mutant BRAF.