Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients
Yu Zhang,
Nina Heinemann,
Franziska Rademacher,
Maxim E. Darvin,
Christian Raab,
Cornelia M. Keck,
Henning Vollert,
Joachim W. Fluhr,
Regine Gläser,
Jürgen Harder,
Martina C. Meinke
Affiliations
Yu Zhang
Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Nina Heinemann
Department of Dermatology, Medical Faculty, Christian-Albrecht University Kiel, Arnold-Heller-Str. 3, 24105 Kiel, Germany
Franziska Rademacher
Department of Dermatology, Medical Faculty, Christian-Albrecht University Kiel, Arnold-Heller-Str. 3, 24105 Kiel, Germany
Maxim E. Darvin
Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Christian Raab
Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Cornelia M. Keck
Department of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany
Henning Vollert
Bioactive Food GmbH, 23795 Bad Segeberg, Germany
Joachim W. Fluhr
Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
Regine Gläser
Department of Dermatology, Medical Faculty, Christian-Albrecht University Kiel, Arnold-Heller-Str. 3, 24105 Kiel, Germany
Jürgen Harder
Department of Dermatology, Medical Faculty, Christian-Albrecht University Kiel, Arnold-Heller-Str. 3, 24105 Kiel, Germany
Martina C. Meinke
Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
The atopic dermatitis (AD) complex pathogenesis mechanism reveals marked changes of certain signaling factors as well as some morphological alterations in the epidermis. Reduced resilience against environmental factors and oxidative stress often makes the treatment with corticosteroids or tacrolismus ointments indispensable. In view of the correlation between oxidative stress and AD pathological factors, antioxidants can be incorporated into AD management strategies. This study investigates a curly kale, apple and green tea-containing natural extract rich in antioxidants for its effects on signaling inflammatory molecules and skin barrier enhancement in human epidermal keratinocytes- (NHEKs) based cell assays. Furthermore, the skin penetration on porcine ears was measured ex vivo using Raman micro spectroscopy. Finally, in a double-blind half-side, placebo-controlled clinical study, the effects of a formulation containing this extract were analyzed for the influence of lesion severity, epidermal barrier function, and pruritus in mild to moderately AD patients. Summarizing our results: The extract reduces expression of inflammatory cytokines in keratinocytes and increases barrier-related molecules. The verum formulation with a very high antioxidant capacity used in AD patients with mild to moderate lesions reduces itching, local SCORAD, and improves barrier function and the hydration of skin lesions.
