Nature Communications (Apr 2020)

Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia

  • Matthew Halvorsen,
  • Ruth Huh,
  • Nikolay Oskolkov,
  • Jia Wen,
  • Sergiu Netotea,
  • Paola Giusti-Rodriguez,
  • Robert Karlsson,
  • Julien Bryois,
  • Björn Nystedt,
  • Adam Ameur,
  • Anna K. Kähler,
  • NaEshia Ancalade,
  • Martilias Farrell,
  • James J. Crowley,
  • Yun Li,
  • Patrik K. E. Magnusson,
  • Ulf Gyllensten,
  • Christina M. Hultman,
  • Patrick F. Sullivan,
  • Jin P. Szatkiewicz

DOI
https://doi.org/10.1038/s41467-020-15707-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Common variants identified by large-scale genomewide association studies cannot account fully account for the heritability of schizophrenia (SCZ). Here, the authors report high-coverage whole-genome sequencing of 1162 SCZ cases and 936 controls and explore the contribution of different types of variants to SCZ.