Tạp chí Khoa học và Công nghệ (Dec 2023)
The cytotoxic activity of lignans and monoterpenoids from the male carica papaya flowers on A549 lung cancer, Hep3B liver cancer, and MCF-7 breast cancer cell lines
Abstract
Two lignans (lariciresinol (1) and dehydrodiconiferyl alcohol (2)), and four monoterpenoids (vitexoid (3), 6-hydroxy-2,6-dimethyl-2,7-octadienoic acid (4), 6-hydroxy-2,6-dimethyloct-7-enoic acid (5), 2,6-dimethylocta-2,7-diene-1,6-diol (6)) from the male Carica papaya flowers are conducted a cytotoxic activity for lung cancer cells (A549), liver cancer cells (Hep3B), and breast cancer cells (MCF-7). The results, lignan (1), and monoterpenoid (3), (6) exhibited medium cytotoxic activity on these cancer cells with IC50 from 34.73±1.55 to 66.12±5.60 µg/mL. Lignan (2) displayed medium cytotoxic activity on MCF-7, Hep3B with IC50 60.85±4.43, 62.32± 5.03 µg/mL, respectively, and weak cytotoxic activity on A549 with IC50 70.99±7.26 µg/mL. Monoterpenoids (4), and (5) showed medium cytotoxic activity on MCF-7 with IC50 54.15±5.89, 67.49±2.41 µg/mL, respectively, and weak cytotoxic activity on A549, and Hep3B with IC50 from 72.25±3.13 to 86.03±7.57 µg/mL. Ellipticine was a positive control.
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