Cell Reports (Nov 2016)
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers
- Hiroto Hatakeyama,
- Sherry Y. Wu,
- Yasmin A. Lyons,
- Sunila Pradeep,
- Wanqin Wang,
- Qian Huang,
- Karem A. Court,
- Tao Liu,
- Song Nie,
- Cristian Rodriguez-Aguayo,
- Fangrong Shen,
- Yan Huang,
- Takeshi Hisamatsu,
- Takashi Mitamura,
- Nicholas Jennings,
- Jeajun Shim,
- Piotr L. Dorniak,
- Lingegowda S. Mangala,
- Marco Petrillo,
- Vladislav A. Petyuk,
- Athena A. Schepmoes,
- Anil K. Shukla,
- Madeline Torres-Lugo,
- Ju-Seog Lee,
- Karin D. Rodland,
- Anna Fagotti,
- Gabriel Lopez-Berestein,
- Chun Li,
- Anil K. Sood
Affiliations
- Hiroto Hatakeyama
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Sherry Y. Wu
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Yasmin A. Lyons
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Sunila Pradeep
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Wanqin Wang
- Department of Cancer Systems Imaging, MDACC, Houston, TX 77030, USA
- Qian Huang
- Department of Cancer Systems Imaging, MDACC, Houston, TX 77030, USA
- Karem A. Court
- Department of Chemical Engineering, University of Puerto Rico-Mayaguez, Mayaguez, PR 00681, Puerto Rico
- Tao Liu
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
- Song Nie
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
- Cristian Rodriguez-Aguayo
- Department of Experimental Therapeutics, MDACC, Houston, TX 77030, USA
- Fangrong Shen
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Yan Huang
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Takeshi Hisamatsu
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Takashi Mitamura
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Nicholas Jennings
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Jeajun Shim
- Department of Systems Biology, MDACC, Houston, TX 77030, USA
- Piotr L. Dorniak
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Lingegowda S. Mangala
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- Marco Petrillo
- Department of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome 00168, Italy
- Vladislav A. Petyuk
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
- Athena A. Schepmoes
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
- Anil K. Shukla
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
- Madeline Torres-Lugo
- Department of Chemical Engineering, University of Puerto Rico-Mayaguez, Mayaguez, PR 00681, Puerto Rico
- Ju-Seog Lee
- Department of Systems Biology, MDACC, Houston, TX 77030, USA
- Karin D. Rodland
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
- Anna Fagotti
- Department of Medicine and Surgery, Catholic University of the Sacred Heart, Rome 00168, Italy
- Gabriel Lopez-Berestein
- Department of Experimental Therapeutics, MDACC, Houston, TX 77030, USA
- Chun Li
- Department of Cancer Systems Imaging, MDACC, Houston, TX 77030, USA
- Anil K. Sood
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USA
- DOI
- https://doi.org/10.1016/j.celrep.2016.10.020
- Journal volume & issue
-
Vol. 17,
no. 6
pp. 1621 – 1631
Abstract
Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.
Keywords
